Posthumus Anna M, Knobbe Tim J, Kremer Daan, Gomes-Neto Antonio W, Dielwart Isabelle J C, Jonker Jip, Doorenbos Caecilia S E, Eisenga Michele F, van Londen Marco, Douwes Rianne M, Nieuwenhuis Lianne M, Annema Coby, de Boer Marieke T, de Borst Martin H, Damman Kevin, Pol Robert A, Gan C Tji, Verschuuren Erik A M, Blokzijl Hans, de Meijer Vincent E, Bakker Stephan J L
Department of Internal Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Department of Surgery, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Eur J Epidemiol. 2025 Jul 2. doi: 10.1007/s10654-025-01258-1.
The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was 50 (± 16) years at transplantation, 55 (± 11) years at living donation and 56 (± 15) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60 months post-transplantation. For living donors, data were collected at pre-donation, donation, 3 months post-donation, and/or 5 or 10 years post-donation.
移植队列生物样本库与队列研究（NCT03272841）是一项正在荷兰格罗宁根大学医学中心开展的前瞻性研究。移植队列旨在确定实体器官移植与捐赠后与健康问题相关的风险因素和生物标志物。此外，该研究还寻求开发新的干预措施，以减轻症状负担并改善长期预后，包括与健康相关的生活质量、心血管并发症、移植物衰竭和死亡率。研究对象包括（联合）心脏、肝脏、肺、肾脏、胰腺和小肠移植受者，以及活体肝脏和肾脏供体，还有已故（多）器官供体。生物样本库包含多种生物材料，包括全血、血清、乙二胺四乙酸血浆、血沉棕黄层、24小时尿液样本、粪便、毛发、指甲和组织。数据收集包括身体和认知评估、广泛的实验室分析、宏基因组测序和问卷调查。移植队列于2015年启动，截至2024年10月共有5143名参与者，其中女性2312名（45%）。移植时的平均年龄为50（±16）岁，活体捐赠时为55（±11）岁，已故捐赠时为56（±15）岁。研究纳入了横断面和纵向生物材料及数据。对于受者，纵向生物材料和数据在移植前、移植时以及移植后3、6、12、24和60个月收集。对于活体供体，数据在捐赠前、捐赠时、捐赠后3个月和/或捐赠后5或10年收集。
