Sun Haoan, Xie Chunbao
School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32, West Section 2, 1 st Ring Road, Chengdu, Sichuan, 610072, China.
Glycoconj J. 2025 Jul 2. doi: 10.1007/s10719-025-10188-9.
DDOST is an important subunit of N-glycosylated oligosaccharyltransferase and is closely related to protein N-glycosylation. Some studies have reported that abnormal expression of DDOST is associated with congenital disorders of glycosylation, solid tumours and other diseases. To better understand the progress of research on DDOST in diseases, we herein provide a comprehensive review of the basic functions of DDOST, interactions molecules, DDOST-congenital disorders of glycosylation (DDOST-CDG) and solid tumours. Our review findings will lay a foundation for researchers to better understand the functions of DDOST and to investigate its specific mechanisms of action.
DDOST是N-糖基化寡糖基转移酶的一个重要亚基，与蛋白质N-糖基化密切相关。一些研究报道，DDOST的异常表达与糖基化先天性疾病、实体瘤及其他疾病有关。为了更好地了解DDOST在疾病研究方面的进展，我们在此全面综述了DDOST的基本功能、相互作用分子、DDOST-糖基化先天性疾病（DDOST-CDG）及实体瘤。我们的综述结果将为研究人员更好地理解DDOST的功能及探究其具体作用机制奠定基础。
