Schiller C M, Adcock C M, Moore R A, Walden R
Toxicol Appl Pharmacol. 1985 Nov;81(2):356-61. doi: 10.1016/0041-008x(85)90173-5.
This study compared the effect of fasting (feed deprivation) and the effect of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on body weight and on key lipid parameters. The time-course study indicated a statistically significant (p less than 0.05) body weight loss in the TCDD-exposed rats 5 days after the oral administration of corn oil with TCDD (60 micrograms/kg body wt). Animals demonstrated a 10% body weight decrease either 1 week after this TCDD administration or after 72 hr of fasting. Marked increases in serum triglyceride and cholesterol were observed only in the TCDD-exposed rats, but not in the 0- or 72-hr fasted control rats. These results indicated that some body weight loss and decreased feed consumption occurred after TCDD exposure, but that the metabolic response, with respect to serum lipid metabolism, was not that of a control rat that had lost a similar amount of body weight due solely to fasting.
本研究比较了禁食（饲料剥夺）以及接触2,3,7,8-四氯二苯并对二恶英（TCDD）对体重和关键脂质参数的影响。时程研究表明，在经口给予含TCDD（60微克/千克体重）的玉米油5天后，接触TCDD的大鼠体重出现具有统计学意义的显著下降（p小于0.05）。在给予TCDD 1周后或禁食72小时后，动物体重下降了10%。仅在接触TCDD的大鼠中观察到血清甘油三酯和胆固醇显著升高，而在禁食0小时或72小时的对照大鼠中未观察到。这些结果表明，接触TCDD后出现了一些体重减轻和饲料消耗减少的情况，但就血清脂质代谢而言，其代谢反应与仅因禁食而体重下降相似的对照大鼠不同。
