Okwampah Rita, Bedzra Kofi Dzorgbenyuie, Gyamfi Oti Kwasi, Ataki James, Kyei Foster, Adarkwah-Yiadom Martin, Sosu Edem, Boateng Emmanuel
Pharmacy Department, Ghana Atomic Energy Commission Hospital, Accra, Ghana.
Cellular and Clinical Research Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Accra, Ghana.
PLoS One. 2025 Jul 2;20(7):e0325846. doi: 10.1371/journal.pone.0325846. eCollection 2025.
Iron is an essential element needed by living organisms to enable their bodies to perform a variety of cellular functions and it is tightly regulated in the body systems of living organisms. One major public health issue in developing countries is the problem of iron deficiency and iron deficiency anaemia in infants, young children, and adults. In sub-Saharan Africa, Ghana is one of the very few countries implementing a universal health insurance programme and therefore, iron (III) polymaltose complex suspension has been one of the medications on the National Health Insurance Scheme (NHIS) drug list. Studies conducted on iron (III) hydroxide with polymaltose in liquid dosage forms in certain parts of the world have been sub-standard. Consequently, this study aims to determine iron (III) in pharmaceutical formulations in some selected haematinics in syrups sold on the Ghanaian market. Seventeen (17) randomly selected products were analysed. Measurements were carried out at 628nm. Results obtained indicated that the concentration of iron (III) ranged between (45.3-49.2) mg/5mL and (57.9-83.4) mg/5mL. At a 95% confidence interval, the population mean of the concentration of the haematinic was between (54 mg/5mL - 66 mg/5mL). As much as anaemia can be cured with iron supplementation, excess iron overload can be very dangerous to the human body therefore Pharmaceutical products should be analysed on a regular basis to ensure their safety and effectiveness.
铁是生物体所需的必需元素，能使它们的身体执行各种细胞功能，并且在生物体的身体系统中受到严格调控。发展中国家的一个主要公共卫生问题是婴儿、幼儿和成年人缺铁及缺铁性贫血问题。在撒哈拉以南非洲，加纳是实施全民健康保险计划的极少数国家之一，因此，聚麦芽糖铁（III）复合物混悬液一直是国家健康保险计划（NHIS）药品清单上的药物之一。在世界某些地区对液体剂型的氢氧化铁（III）与聚麦芽糖进行的研究不符合标准。因此，本研究旨在测定加纳市场上销售的糖浆中一些选定补血剂的药物制剂中的铁（III）。对随机选择的17种产品进行了分析。在628nm处进行测量。获得的结果表明，铁（III）的浓度范围在（45.3 - 49.2）mg/5mL和（57.9 - 83.4）mg/5mL之间。在95%置信区间，补血剂浓度的总体均值在（54mg/5mL - 66mg/5mL）之间。尽管补充铁可以治愈贫血，但铁过载过多对人体可能非常危险，因此药品应定期进行分析以确保其安全性和有效性。
