Gordon C J, Long M D, Stead A G
Toxicol Lett. 1985 Oct;28(1):9-15. doi: 10.1016/0378-4274(85)90003-7.
CBA/J mice were injected intraperitoneally (i.p.) with the formamidine insecticide chlordimeform (CDM) while colonic temperature, preferred ambient temperature (Ta), and lethality were monitored. In the first experiment there was a dose-dependent decrease in colonic temperature when measured 60 min after administering CDM doses of 0, 15, 30, 60, and 75 mg/kg. The hypothermic effect of CDM was more pronounced at a Ta of 20 degrees C than at 30 degrees C. In the second experiment, CDM at doses greater than 30 mg/kg caused a dose-dependent reduction in preferred Ta from the normal value of approx. 30 degrees C to approx. 22 degrees C. Thus, the CDM-treated mouse lowered body temperature by selecting a cool Ta which accelerated the hypothermic effect. In the final experiment, a 90 mg/kg i.p. injection of CDM (the approximate LD50 dose) caused 10% and 0% mortality at a Ta of 20 and 30 degrees C, respectively, and 80% mortality at a Ta of 35 degrees C. It is concluded that the physiological and behavioral response to CDM administration, i.e., selecting a cool Ta and lowering body temperature, may be beneficial to survival.
给CBA/J小鼠腹腔注射（i.p.）甲脒类杀虫剂杀虫脒（CDM），同时监测结肠温度、偏好环境温度（Ta）和致死率。在第一个实验中，在给予0、15、30、60和75 mg/kg剂量的CDM 60分钟后测量结肠温度，发现结肠温度呈剂量依赖性下降。CDM的低温效应在20℃的Ta下比在30℃时更明显。在第二个实验中，剂量大于30 mg/kg的CDM导致偏好Ta从约30℃的正常值呈剂量依赖性降低至约22℃。因此，经CDM处理的小鼠通过选择凉爽的Ta来降低体温，这加速了低温效应。在最后一个实验中，腹腔注射90 mg/kg的CDM（近似LD50剂量）在20℃和30℃的Ta下分别导致10%和0%的死亡率，在35℃的Ta下导致80%的死亡率。得出的结论是，对CDM给药的生理和行为反应，即选择凉爽的Ta和降低体温，可能有利于生存。
