Wysocki H, Kiczka W, Wierusz-Wysocka B, Szczepanik A, Czarnecki J
Thymus. 1985;7(5):271-8.
The influence of thymus extract (TFX) on phagocytosis and bactericidal capacity of polymorphonuclear neutrophils (PMN) from patient with insulin-dependent diabetes was studied. In previous observations PMN from these patients revealed the serum-related defect of bacterial killing. The preincubation of cells with standard dose of TFX significantly increased ingestion rate and recovered the bactericidal capacity to normal values. The augmentation of bactericidal capacity due to preincubation with TFX appeared to be dose-dependent and not related to other blood cells participation. The increase of bacterial killing was also evident, when TFX was applied after phagosome formation. The presented studies indicate that, among numerous peptides, thymus extracts contain those exerting their hormone-like activity on polymorphonuclear neutrophils. The observations may be of clinical importance.
研究了胸腺提取物（TFX）对胰岛素依赖型糖尿病患者多形核中性粒细胞（PMN）吞噬作用和杀菌能力的影响。在先前的观察中，这些患者的PMN显示出与血清相关的细菌杀伤缺陷。用标准剂量的TFX对细胞进行预孵育可显著提高吞噬率，并使杀菌能力恢复到正常水平。由于用TFX进行预孵育而导致的杀菌能力增强似乎呈剂量依赖性，且与其他血细胞的参与无关。当在吞噬体形成后应用TFX时，细菌杀伤的增加也很明显。目前的研究表明，在众多肽类中，胸腺提取物含有对多形核中性粒细胞发挥其类激素活性的物质。这些观察结果可能具有临床意义。
