Fujioka Ikumi, Uchida Kenji
R&D Center, Yotsuba Milk Products Co., Ltd, 465-1 Wattsu, Kitahiroshima, Hokkaido, 061-1264, Japan.
Sci Rep. 2025 Jul 2;15(1):23393. doi: 10.1038/s41598-025-07783-z.
Lactococcus cremoris YRC3780, isolated from kefir, likely improves the hypothalamic-pituitary-adrenal axis response to acute psychological stress by acting on intestinal immune cells and promoting cytokine production. Here we examined the effectiveness of YRC3780 on the stress response in healthy Japanese adults. We investigated the effects of daily YRC3780 intake on the stress response in a randomized, placebo-controlled, double-blind, parallel-group study of 107 healthy Japanese adults (54 in the YRC3780 group and 53 in the placebo group) who had an initial positive Uchida-Kraepelin (U-K) test stress response. After 8 weeks, the POMS2 Total Mood Disturbance (TMD) score after the U-K test and the change in score from baseline score were significantly better in the YRC3780 group than in the placebo. The YRC3780 group showed significant improvements in the POMS2 TMD and in five POMS2 subscores difference before and after the U-K test at 8 weeks. Daily YRC3780 intake significantly improved the stress response in healthy Japanese adults who had an initial stress response in the U-K test.
从开菲尔中分离出的乳酸乳球菌YRC3780可能通过作用于肠道免疫细胞并促进细胞因子产生，改善下丘脑-垂体-肾上腺轴对急性心理应激的反应。在此，我们研究了YRC3780对健康日本成年人应激反应的有效性。我们在一项随机、安慰剂对照、双盲、平行组研究中，调查了107名初始内田-克莱佩林（U-K）测试应激反应呈阳性的健康日本成年人（YRC3780组54人，安慰剂组53人）每日摄入YRC3780对应激反应的影响。8周后，YRC3780组U-K测试后的POMS2总情绪紊乱（TMD）评分以及与基线评分相比的得分变化均显著优于安慰剂组。YRC3780组在8周时U-K测试前后的POMS2 TMD及五个POMS2子评分差异方面均有显著改善。每日摄入YRC3780显著改善了初始U-K测试中有应激反应的健康日本成年人的应激反应。
