Zhang Fan, Xue Yuan, Li Wenjian
Department of Endocrinology, Changzhou Third People's Hospital, Changzhou, 213001, China.
Department of Clinical Nutrition, Changzhou Third People's Hospital, Changzhou, 213001, China.
BMC Geriatr. 2025 Jul 2;25(1):444. doi: 10.1186/s12877-025-06115-0.
This study investigated the effects of sleep duration and sleep disorders on metabolic dysfunction-associated steatotic liver disease (MASLD) in older adults and provided a scientific basis for the development of targeted health management strategies.
The present study utilized data from the National Health and Nutrition Examination Survey database of older adults from 2005 to 2014 and included 4,731 participants. The assessment of sleep duration and sleep disorders was conducted using the “Sleep Disorders” questionnaire, while the diagnosis of MASLD was determined based on the fatty liver index and cardiometabolic criteria. The relationship between sleep duration, sleep disorders, and MASLD was analyzed using logistic regression modeling, and the dose-response relationship between sleep duration and MASLD was explored using the restricted cubic spline (RCS) model. Furthermore, subgroup analyses were conducted to investigate the association between sleep disorders and MASLD across diverse population characteristics.
The study indicated that individuals who slept less than six hours per night exhibited a 21% higher prevalence of MASLD than those who slept six to eight hours. Notably, the prevalence increased substantially, by 38%, in individuals who slept more than eight hours per night. The presence of sleep disorders in individuals was found to be associated with a 2.38-fold elevated prevalence of MASLD compared to those without sleep disorders. Furthermore, the RCS analysis revealed a non-linear relationship between sleep duration and MASLD, indicating an overall “U”-shaped trend with a turning point at 7 h. Subgroup analyses demonstrated that the association remained significant in all subgroups except those with low education levels and stroke patients.
The present study found that short or long sleep duration and the presence of sleep disorders were significantly associated with MASLD in older adults. The result provides a rationale for the prevention of MASLD in the elderly population. The study suggests that clinical practice should focus on the potential value of sleep assessment in managing metabolic liver disease.
Not applicable.
本研究调查了睡眠时间和睡眠障碍对老年人代谢功能障碍相关脂肪性肝病（MASLD）的影响，并为制定有针对性的健康管理策略提供科学依据。
本研究利用了2005年至2014年全国老年人健康与营养检查调查数据库中的数据，纳入了4731名参与者。使用“睡眠障碍”问卷对睡眠时间和睡眠障碍进行评估，而MASLD的诊断则基于脂肪肝指数和心脏代谢标准。使用逻辑回归模型分析睡眠时间、睡眠障碍与MASLD之间的关系，并使用受限立方样条（RCS）模型探索睡眠时间与MASLD之间的剂量反应关系。此外，进行亚组分析以研究不同人群特征中睡眠障碍与MASLD之间的关联。
研究表明，每晚睡眠时间少于6小时的个体患MASLD的患病率比睡眠时间为6至8小时的个体高21%。值得注意的是，每晚睡眠时间超过8小时的个体患病率大幅上升，增加了38%。与没有睡眠障碍的个体相比，有睡眠障碍的个体患MASLD的患病率高出2.38倍。此外，RCS分析显示睡眠时间与MASLD之间存在非线性关系，总体呈“U”形趋势，转折点为7小时。亚组分析表明，除了低教育水平者和中风患者外，所有亚组中的关联均显著。
本研究发现，睡眠时间过短或过长以及存在睡眠障碍与老年人MASLD显著相关。该结果为预防老年人群中的MASLD提供了理论依据。该研究表明，临床实践应关注睡眠评估在管理代谢性肝病中的潜在价值。
不适用。
