Sarkoohi Zahra, Bastan Mohammad-Mahdi, Khajuei Gharaei Mohammad Amin, Iranmanesh Mahsa, Adinepour Arya, Khajezade Reyhane, Bahri Faegheh, Akhlaghi Fatemeh, Kadkhodamanesh Azin, Pourghadamyari Hossein, Sharifi Hamid, Eslami Omid, Nejadghaderi Seyed Aria
Student Research Committee, Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
J Health Popul Nutr. 2025 Jun 18;44(1):207. doi: 10.1186/s41043-025-00973-5.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition marked by excess liver fat, ranging from simple steatosis to non-alcoholic steatohepatitis. Updated reports on the epidemiology of MASLD in the Middle East and North Africa (MENA) region are needed. This study aimed to report the trends in the MASLD burden in the MENA region from 1990 to 2021, as well as age and sex patterns and their association with the sociodemographic index (SDI).
Data on the incidence, prevalence, disability-adjusted life years (DALYs), and mortality of MASLD in 21 countries within the MENA region from 1990 to 2021 were extracted from the GBD 2021 study. The relationship with the SDI and the burden attributable to risk factors, such as high fasting plasma glucose and smoking, were examined.
Between 1990 and 2021, the MENA region experienced a 13.8% increase in the age-standardized incidence rate, reaching 1,037.6 per 100,000 population. The age-standardized prevalence saw a rise of 26.4%. Women experienced a higher increase in incidence than men. The highest rates of DALYs were observed among older adults. Countries with a high SDI faced a greater disease burden. High fasting plasma glucose accounted for the largest burden of MASLD.
The study found that the incidence and prevalence of MASLD in the MENA region increased significantly from 1990 to 2021, especially in areas with high SDI. High fasting plasma glucose was the most significant attributable risk factor, highlighting the need for metabolic interventions.
Not applicable.
代谢功能障碍相关脂肪性肝病（MASLD）是一种以肝脏脂肪过多为特征的疾病，范围从单纯性脂肪变性到非酒精性脂肪性肝炎。需要有关中东和北非（MENA）地区MASLD流行病学的最新报告。本研究旨在报告1990年至2021年MENA地区MASLD负担的趋势，以及年龄和性别模式及其与社会人口指数（SDI）的关联。
从全球疾病负担（GBD）2021研究中提取了1990年至2021年MENA地区21个国家MASLD的发病率、患病率、伤残调整生命年（DALYs）和死亡率数据。研究了其与SDI的关系以及高空腹血糖和吸烟等危险因素所致的负担。
1990年至2021年期间，MENA地区年龄标准化发病率上升了13.8%，达到每10万人1037.6例。年龄标准化患病率上升了26.4%。女性发病率的增幅高于男性。DALYs率在老年人中最高。SDI高的国家面临更大的疾病负担。高空腹血糖占MASLD的最大负担。
研究发现，1990年至2021年期间，MENA地区MASLD的发病率和患病率显著增加，尤其是在SDI高的地区。高空腹血糖是最主要的可归因危险因素，突出了代谢干预的必要性。
不适用。
