Xu Shenyuan, Nan Ding, Liu Ruiqi, Liu Chenting, Hu Yuefeng, Huang Luanluan, Chen Xiaoyan, Sheng Hailong, Lu Yanwei, Zhang Haibo
Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Hangzhou Medical College, Hangzhou, Zhejiang, China.
J Transl Med. 2025 Jul 2;23(1):725. doi: 10.1186/s12967-025-06746-2.
In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the accurate distribution of genetic material to the two daughter cells. NUSAP1 is located on chromosome 15q15.1 and is typically expressed in proliferating cells, suggesting a potential oncogenic role. Studies have shown that NUSAP1 plays a significant role in various cancers, including breast cancer, cervical cancer, lung cancer, prostate cancer, and hepatocellular carcinoma. Furthermore, NUSAP1 may serve as a promising biomarker for cancer diagnosis and prognosis. In this review, we discuss the roles and mechanisms of NUSAP1 in human cancers.
近年来，癌症的发病率有所上升，早期诊断和治疗是癌症治疗的关键。核仁与纺锤体相关蛋白1（NUSAP1）是一种关键的有丝分裂调节因子。NUSAP1与微管结合并介导其与染色体的附着，确保遗传物质准确分配到两个子细胞中。NUSAP1位于15号染色体q15.1位置，通常在增殖细胞中表达，提示其具有潜在的致癌作用。研究表明，NUSAP1在包括乳腺癌、宫颈癌、肺癌、前列腺癌和肝细胞癌在内的多种癌症中发挥重要作用。此外，NUSAP1可能是一种有前景的癌症诊断和预后生物标志物。在本综述中，我们讨论了NUSAP1在人类癌症中的作用和机制。
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