Liu Zehao, Weng Yan, Liu Funing, Jiang Dezhou, Wu Chunmei, Chen Yong, Duan Xiaoxia, Zhong Qing
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Anesthesiology, The People's Hospital of Jianyang, Jianyang, China.
Front Neurol. 2025 Jun 18;16:1586995. doi: 10.3389/fneur.2025.1586995. eCollection 2025.
This study aimed to explore the efficacy and safety of short-term Spinal Cord Stimulation (stSCS) and Pulsed Radiofrequency (PRF) in the treatment of postherpetic neuralgia (PHN).
We searched the PubMed, Cochrane Library, Web of Science, Embase, China Biological Medicine Database (CBM-disk), Chinese National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for randomized controlled trials (RCTs) from the establishment of the database to August 1, 2024. Review Manager 5.4 and Stata 18.0 were used for the meta-analysis.
In total, eight randomized controlled trials comprising 479 patients were included. Meta-analysis showed that compared with PRF, stSCS had better pain relief ( < 0.01), lower Pain Rating Index Affective (PRI-A) score ( < 0.01), lower Pain Rating Index Sensory (PRI-S) score ( = 0.002), better sleep quality ( = 0.02), higher effective rate ( < 0.01), and lower incidence of postoperative complications ( = 0.007). However, complete remission rate ( = 0.24) after the two treatment methods were similar between the two groups. Moreover, stSCS treatment is more expensive.
In general, stSCS is a more effective and safe method for the treatment of PHN, but its high cost is an unavoidable problem. Each method has advantages and disadvantages that should be considered comprehensively in clinical practice.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024576536.
本研究旨在探讨短期脊髓刺激（stSCS）和脉冲射频（PRF）治疗带状疱疹后神经痛（PHN）的疗效和安全性。
我们检索了PubMed、Cochrane图书馆、Web of Science、Embase、中国生物医学数据库（CBM-disk）、中国知网（CNKI）、万方和维普数据库，以获取从数据库建立至2024年8月1日的随机对照试验（RCT）。使用Review Manager 5.4和Stata 18.0进行荟萃分析。
共纳入8项随机对照试验，包括479例患者。荟萃分析显示，与PRF相比，stSCS在缓解疼痛方面效果更好（<0.01），疼痛评级指数情感（PRI-A）得分更低（<0.01），疼痛评级指数感觉（PRI-S）得分更低（=0.002），睡眠质量更好（=0.02），有效率更高（<0.01），术后并发症发生率更低（=0.007）。然而，两组间两种治疗方法后的完全缓解率（=0.24）相似。此外，stSCS治疗费用更高。
总体而言，stSCS是治疗PHN更有效且安全的方法，但其高成本是一个不可避免的问题。每种方法都有优缺点，在临床实践中应综合考虑。
