Tao Yixuan, Liu Dongling, Shi Qianhan, Sun Qinghua, Liu Cuiqing, Zeng Xiang
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Appl Environ Microbiol. 2025 Jul 23;91(7):e0037225. doi: 10.1128/aem.00372-25. Epub 2025 Jul 3.
Lead (Pb) is a hazardous heavy metal with no known safe threshold for exposure or consumption, posing significant risks to human health. Pb exposure can cause multiple system damage, depending on exposure levels, duration, and its high bioavailability and bioaccumulative potential. Gastrointestinal tract serves as a primary site for Pb absorption, making it particularly vulnerable to Pb-induced damage, including disruption of gut microbiota composition and metabolic function. This study briefly summarizes the detrimental effects of Pb gut homeostasis, microbial ecology, and host metabolism, which, in turn, further contribute to systemic toxicity. Notably, Pb exposure compromises intestinal barrier integrity, increasing gut permeability and facilitating the translocation of harmful biomolecules into systemic circulation, thereby exacerbating organ dysfunction. Importantly, we underscore that dietary and nutritional interventions such as fiber, probiotic, and vitamin C supplementation is a practicable and effective strategy for mitigating or preventing Pb toxicity.
铅（Pb）是一种有害重金属，其暴露或摄入不存在已知的安全阈值，对人类健康构成重大风险。根据暴露水平、持续时间以及其高生物利用度和生物累积潜力，铅暴露可导致多系统损害。胃肠道是铅吸收的主要部位，使其特别容易受到铅诱导的损害，包括肠道微生物群组成和代谢功能的破坏。本研究简要总结了铅对肠道稳态、微生物生态和宿主代谢的有害影响，而这些反过来又进一步导致全身毒性。值得注意的是，铅暴露会损害肠道屏障完整性，增加肠道通透性并促进有害生物分子进入体循环，从而加剧器官功能障碍。重要的是，我们强调，诸如补充纤维、益生菌和维生素C等饮食和营养干预措施是减轻或预防铅毒性的切实可行且有效的策略。
