Institute-Associated Research Group "Cell Adhesion and Cell Polarity", Institute of Medical Biochemistry, ZMBE, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, Germany.
Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, D-48419 Münster, Germany.
Cells. 2023 Nov 24;12(23):2701. doi: 10.3390/cells12232701.
Tight junctions (TJ) are cell-cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity and unexpected dynamic regulation, which allows the TJs to maintain a barrier in the presence of physiological forces and in response to perturbations. Cell-cell adhesion receptors play key roles during the dynamic regulation of TJs. They connect individual cells within cellular sheets and link sites of cell-cell contacts to the underlying actin cytoskeleton. Recent findings support the roles of adhesion receptors in transmitting mechanical forces and promoting phase separation. In this review, we discuss the newly discovered functions of cell adhesion receptors localized at the TJs and their role in the regulation of the barrier function.
紧密连接（TJ）是细胞-细胞黏附结构，定义了屏障形成上皮和内皮的通透性。与这种看似静态的功能相反，TJ 显示出惊人的高分子复杂性和意想不到的动态调节，这使得 TJ 在存在生理力和响应于扰动的情况下能够维持屏障。细胞-细胞黏附受体在 TJ 的动态调节中发挥关键作用。它们将细胞片内的各个细胞连接起来，并将细胞-细胞接触部位与下面的肌动蛋白细胞骨架连接起来。最近的发现支持黏附受体在传递机械力和促进相分离中的作用。在这篇综述中，我们讨论了位于 TJ 处的细胞黏附受体的新发现功能及其在调节屏障功能中的作用。
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