Song Jonathan J, Kielhofner Jane, Qian Zhiyu Jason, Gu Catherine, Boysen William, Chang Steven, Dahl Douglas, Eswara Jairam, Haleblian George, Wintner Anton, Wollin Daniel A
Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Department of Urology, Brigham and Women's Hospital, Boston, MA, USA.
World J Urol. 2025 Jul 3;43(1):409. doi: 10.1007/s00345-025-05782-3.
While age has previously been demonstrated to not be a contraindication for pyeloplasty, the association of age and outcomes has been mixed. We analyzed rates of diverse subjective and objective outcome measures in older adults after robotic-assisted laparoscopic pyeloplasty for ureteropelvic junction obstruction (UPJO).
We conducted an observational retrospective study of patients who underwent robotic-assisted laparoscopic pyeloplasty at our two-center hospital system from 2015 to 2023. Stratified by age (≥ 65 vs. < 65), patients were compared by pre- and intraoperative characteristics as well as postoperative outcomes: rate of complications, ED visits, and reoperation, as well as change in flank pain, hydronephrosis, half-life of clearance, split renal function, and creatinine.
Of 214 adults who underwent pyeloplasty for treatment of UPJO, 52 (24.3%) patients were aged ≥ 65. Patients aged ≥ 65 presented more frequently with hypertension (75.0% vs. 32.1%), cardiovascular disease (67.3% vs. 21.0%), previous abdominal surgery (76.9% vs. 47.5%). By age, no significant differences were observed in laterality of UPJO, surgical approach, presence of crossing vessel, estimated blood loss, drain duration, stent size or length, rate of minor or major complications, or length of stay. By age, no differences were observed in any postoperative outcomes.
Although patients over 65 who underwent robotic-assisted laparoscopic pyeloplasty for UPJO more frequently presented with hypertension, cardiovascular disease, prior abdominal surgery, risk of poor outcomes remained similar to that of younger patients. Future research should focus on establishing standardized success criteria to further enhance care and facilitate comparability across studies.
虽然先前已证明年龄并非肾盂成形术的禁忌证,但年龄与手术结果之间的关联尚无定论。我们分析了老年患者在接受机器人辅助腹腔镜肾盂成形术治疗输尿管肾盂连接部梗阻(UPJO)后的各种主观和客观结果指标。
我们对2015年至2023年在我们的双中心医院系统接受机器人辅助腹腔镜肾盂成形术的患者进行了一项观察性回顾性研究。按年龄分层(≥65岁与<65岁),比较患者的术前和术中特征以及术后结果:并发症发生率、急诊就诊次数、再次手术率,以及胁腹痛、肾积水、清除半衰期、分肾功能和肌酐的变化。
在214例接受肾盂成形术治疗UPJO的成人患者中,52例(24.3%)年龄≥65岁。≥65岁的患者更常出现高血压(75.0%对32.1%)、心血管疾病(67.3%对21.0%)、既往腹部手术史(76.9%对47.5%)。按年龄划分,在UPJO的侧别、手术方式、交叉血管的存在、估计失血量、引流持续时间、支架尺寸或长度、轻微或严重并发症发生率或住院时间方面未观察到显著差异。按年龄划分,在任何术后结果方面均未观察到差异。
尽管接受机器人辅助腹腔镜肾盂成形术治疗UPJO的65岁以上患者更常出现高血压、心血管疾病、既往腹部手术史,但其不良结果的风险与年轻患者相似。未来的研究应侧重于建立标准化的成功标准,以进一步改善治疗并促进研究间的可比性。