García-Domínguez Mario
Program of Immunology and Immunotherapy, CIMA-Universidad de Navarra, Pamplona, Spain.
Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain.
Inflammopharmacology. 2025 Jul 3. doi: 10.1007/s10787-025-01827-6.
Opiorphin peptide is a promising candidate in therapeutic pain modulation, with a special emphasis in the treatment of neuropathic pain. Neuropathic pain originates from damage or dysfunction within the nervous system and is well known for its resistance to conventional analgesics. Opiorphin acts by inhibiting two major enzymes responsible for the degradation of enkephalins, peptides that play a key role in pain relief: neutral endopeptidase and aminopeptidase N. By selectively enhancing endogenous opioids, opiorphin provides a novel strategy that opens new pathways in the pursuit of effective pain relief while minimizing the risks of tolerance and addiction. Research on the efficacy of opiorphin has demonstrated promising effects in the treatment of neuropathic pain, which often resists the action of conventional drugs. While pre-clinical studies have showed the therapeutic potential of this peptide, further research, including clinical trials, will be essential to the exploration of its pharmacodynamics, long-term safety, and effectiveness in the treatment of neuropathic pain. Emerging evidence could lead to the development of a new generation of analgesics that show fewer side effects than conventional opioids.
阿片肤素肽是治疗疼痛调节方面一个很有前景的候选药物，尤其在治疗神经性疼痛方面备受关注。神经性疼痛源于神经系统内的损伤或功能障碍，以对传统镇痛药具有抗性而闻名。阿片肤素通过抑制两种负责脑啡肽降解的主要酶发挥作用，脑啡肽是在缓解疼痛中起关键作用的肽：中性内肽酶和氨肽酶N。通过选择性增强内源性阿片类物质，阿片肤素提供了一种新策略，在追求有效缓解疼痛的同时，将耐受性和成瘾风险降至最低，开辟了新途径。对阿片肤素疗效的研究已证明其在治疗神经性疼痛方面有显著效果，而神经性疼痛通常对传统药物有抗性。虽然临床前研究已显示出这种肽的治疗潜力，但进一步的研究，包括临床试验，对于探索其药效学、长期安全性以及治疗神经性疼痛的有效性至关重要。新出现的证据可能会促使开发出新一代副作用比传统阿片类药物更少的镇痛药。
