Manz M, Kuhl A J, Lüderitz B
Z Kardiol. 1985 Sep;74(9):500-5.
The electrophysiologic effects of sotalol were studied in 11 patients with Wolff-Parkinson-White syndrome and 9 patients with AV nodal reentrant tachycardia. Electrophysiologic studies were performed before and after intravenous infusion of 80 mg sotalol over a period of 5 minutes. Sotalol prolonged the effective refractory period of the right atrium and the right ventricle. Both AV node and accessory pathway conduction were depressed by sotalol in antegrade and retrograde directions. Induction of reentrant tachycardia was prevented in 6 of 18 patients. The rate of reentrant tachycardia decreased from 182 +/- 29/min to 153 +/- 14/min (p less than 0.01) and the ventricular rate during atrial fibrillation from 148 +/- 14/min to 112 +/- 12/min (p less than 0.05). Sotalol exhibited a depressant effect on all parts of the reentrant circuit: atrium, ventricle, AV node, and accessory pathway. Thus, sotalol is effective in the therapy of patients with recurrent supraventricular tachycardias.
对11例预激综合征患者和9例房室结折返性心动过速患者进行了索他洛尔的电生理效应研究。在5分钟内静脉输注80毫克索他洛尔前后进行了电生理研究。索他洛尔延长了右心房和右心室的有效不应期。索他洛尔在顺行和逆行方向均抑制房室结和旁路传导。18例患者中有6例预防了折返性心动过速的诱发。折返性心动过速的速率从182±29次/分钟降至153±14次/分钟（p<0.01），房颤时的心室率从148±14次/分钟降至112±12次/分钟（p<0.05）。索他洛尔对折返环路的所有部分：心房、心室、房室结和旁路均有抑制作用。因此，索他洛尔对复发性室上性心动过速患者的治疗有效。
