Kühlkamp V, Mewis C, Mayer F, Seipel L
Medizinische Klinik Abt. III, Eberhard-Karls-Universität, Tübingen.
Z Kardiol. 1990 Oct;79(10):725-31.
The electrophysiologic effects of the new class-I antiarrhythmic drug pentisomide were investigated after intravenous (5 mg/kg) application in nine patients with atrioventricular nodal reentrant tachycardia and six patients with atrioventricular tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle (ERP-RV), the AV-node (ERP-AVN) and QT interval. Intranodal (AH-interval) and infranodal conduction time (HV-interval), effective refractory period of the right atrium (ERP-A), QRS duration, antegrade effective refractory period of the accessory pathway (ERP-Kent), ventricular cycle length during atrial fibrillation and tachycardia cycle length were significantly (P less than 0.05) increased. Intravenous pentisomide prevented induction of the tachycardia in 5/9 patients with atrioventricular nodal tachycardia and in 2/6 patients with atrioventricular tachycardia. The electrophysiologic properties of pentisomide indicate that it might be a useful drug in the treatment of supraventricular tachycardia.
在9例房室结折返性心动过速患者和6例房室性心动过速患者静脉注射（5毫克/千克）新型I类抗心律失常药物喷替索米后，对其电生理效应进行了研究。喷替索米未改变窦性周期长度、右心室有效不应期（ERP-RV）、房室结（ERP-AVN）和QT间期。结内（AH间期）和结下传导时间（HV间期）、右心房有效不应期（ERP-A）、QRS时限、旁路前向有效不应期（ERP-Kent）、房颤时的心室周期长度和心动过速周期长度均显著（P<0.05）增加。静脉注射喷替索米可使5/9例房室结性心动过速患者和2/6例房室性心动过速患者的心动过速诱发受到抑制。喷替索米的电生理特性表明，它可能是治疗室上性心动过速的一种有用药物。
