Krafft W, Wagner F, Marzotko F, Cotte U, Behling H, Brückmann D
Zentralbl Gynakol. 1985;107(17):1041-9.
In a retrospective long term study the tumorbiological importance of metastases in lymph-nodes of cervix cancer have been examined. The base of this presentation consists of a follow up study of 855 patients suffering from cervix cancer (stage I 557 pat., stage II 298 pat.) in relation to lymph-node-metastases. Metastases in 9,9% in stage I and in 18,4% in stage II could been proved histologically. The 5-year-survival-rate decreased in stage Ib from 89 (T1 No Mo) to 59% (T1 Ni Mo) and in stage II respectively (T2a No Mo) from 73 to 27% (T2a Ni Mo) and from 89 (T2b Ni Mo) to 52% (T2b Ni Mo). About 59% of relapses appeared in the treated region of the pelvis. In cases of adenomatous and dedifferentiated cancer 4% more regional metastases could be found than in squamous cell cancers. By means of post-operative irradiation (especially telecobalt-therapy) the relapse-free interval could be prolonged about one to two years. Recently tumourbiological knowledge is involved in the discussion. The appearance of lymph-node metastases represents the worst prognostic feature for the cure and the life of the patient suffering from cervical cancer.
在一项回顾性长期研究中，对子宫颈癌淋巴结转移的肿瘤生物学重要性进行了检查。本报告的依据是对855例子宫颈癌患者（I期557例，II期298例）进行的随访研究，涉及淋巴结转移情况。I期有9.9%、II期有18.4%的转移经组织学证实。I b期的5年生存率从89%（T1 No Mo）降至59%（T1 Ni Mo），II期（T2a No Mo）分别从73%降至27%（T2a Ni Mo），以及从89%（T2b Ni Mo）降至52%（T2b Ni Mo）。约59%的复发出现在盆腔治疗区域。在腺癌和未分化癌病例中，区域转移比鳞状细胞癌多4%。通过术后放疗（尤其是远距离钴治疗），无复发生存期可延长约一至两年。最近肿瘤生物学知识也被纳入了讨论。淋巴结转移的出现是子宫颈癌患者治愈和生存的最不利预后特征。
