Leonard James A, Blumenthal Daniel L, Behzadpour Hengameh K, Bauman Nancy M, Preciado Diego
Department of Pediatric Otolaryngology, Children's National Medical Center, George Washington University School of Medicine, USA.
Department of Pediatric Otolaryngology, Children's National Medical Center, USA.
Int J Pediatr Otorhinolaryngol. 2025 Aug;195:112452. doi: 10.1016/j.ijporl.2025.112452. Epub 2025 Jun 30.
Management of laryngotracheal stenosis in the infant is challenging for patients, families, and providers. This study was designed to evaluate the impact of patient characteristics and surgical techniques on rates of tracheostomy decannulation and avoidance in infants managed with laryngotracheal reconstruction (LTR).
Charts were retrospectively reviewed for all pediatric patients with laryngotracheal stenosis managed with open airway surgery at a tertiary children's hospital between 2008 and 2021. The primary outcome evaluated was tracheostomy decannulation and avoidance.
Forty infants were included in the study with a median age of 7.5 months and weight of 6.7 kg. More than half (62.5 %) of the infants were Black or African American. Seventy percent of patients included had grade 3 Myer-Cotton subglottic stenosis. Infants, compared with children (n = 153), were far less likely to have a tracheostomy prior to LTR (22.5 % vs 73.2 %, p < 0.001), undergo double stage surgery (17.5 % vs 51 %, p = 0.001), or use stenting post operatively (7.5 % vs 34.6 %, p = 0.001). Rates of tracheostomy decannulation and avoidance in infants were similar to those in children treated with LTR (82.5 % vs 75.2 %, p = 0.404). In infants, the rate of tracheostomy decannulation and avoidance was far lower in those treated with double stage surgery (OR 0.075, CI 0.01-0.47, p = 0.008), with glottic stenosis (OR 0.103, CI 0.015-0.62, p = 0.015), or multilevel stenosis (OR 0.075, CI 0.01-0.47, p = 0.008).
We present a large cohort of infants undergoing LTR for tracheostomy decannulation and avoidance demonstrating efficacy with a reduced chance of success with glottic or multilevel stenosis.
对于患者、家庭和医疗服务提供者而言,婴儿喉气管狭窄的管理颇具挑战性。本研究旨在评估患者特征和手术技术对接受喉气管重建术(LTR)的婴儿气管造口脱管率及避免气管造口的影响。
回顾性分析2008年至2021年期间在一家三级儿童医院接受气道开放手术治疗的所有小儿喉气管狭窄患者的病历。评估的主要结局是气管造口脱管及避免气管造口。
该研究纳入了40例婴儿,中位年龄为7.5个月,体重为6.7千克。超过一半(62.5%)的婴儿为黑人或非裔美国人。纳入的患者中有70%患有3级迈耶-科顿声门下狭窄。与儿童(n = 153)相比,婴儿在LTR术前进行气管造口的可能性要低得多(22.5%对73.2%,p < 0.001),接受二期手术的可能性较低(17.5%对51%,p = 0.001),术后使用支架的可能性也较低(7.5%对34.6%,p = 0.001)。婴儿的气管造口脱管率及避免气管造口的比例与接受LTR治疗的儿童相似(82.5%对75.2%,p = 0.404)。在婴儿中,接受二期手术、有声门狭窄或多级狭窄的患者气管造口脱管及避免气管造口的比例要低得多(比值比0.075,可信区间0.01 - 0.47,p = 0.008),有声门狭窄的患者(比值比0.103,可信区间0.015 - 0.62,p = 0.015),或多级狭窄的患者(比值比0.075,可信区间0.01 - 0.47,p = 0.008)。
我们展示了一大组接受LTR以实现气管造口脱管及避免气管造口的婴儿队列,证明了其有效性,但声门或多级狭窄患者成功的机会降低。