Wang Yu-Tong, Zheng Sheng-Yuan, Luo Yan, Xiao Wen-Feng, Huang Cheng, Li Yu-Sheng
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Clinical Medicine, Xiangya Medicine School, Central South University, Changsha, Hunan, China.
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ageing Res Rev. 2025 Sep;111:102822. doi: 10.1016/j.arr.2025.102822. Epub 2025 Jul 1.
Osteoimmunology is an interdisciplinary study of the interaction between the immune system and the skeletal system, aiming to reveal the immune regulation mechanisms that affect bone health and disease. Aging is a macro concept, which is not limited to the senescence of cells, but also includes the aging of the body as a whole. Studies have shown that aging can affect osteoimmune function through various mechanisms such as affecting the bone marrow microenvironment, causing immune cell dysfunction, triggering inflammatory responses, and destroying bone homeostasis, leading to the occurrence of bone diseases. Therefore, this review provides a comprehensive introduction to the related cells and mechanisms of osteoimmunology, elaborating in detail the characteristics of senescence of immune cells and bone cells, the mutual influences between bone cells and immune cells and the impact of aging on osteoimmune function. On this basis, we propose new insights on the mechanisms of aging and osteoimmune pathogenesis in Acute myeloid leukemia, Rheumatoid Arthritis, Osteoporosis and Periodontitis, and propose anti-aging strategies for the treatment of osteoimmune-related diseases, which provides a new idea for the treatment of osteoimmune-related diseases.
骨免疫学是对免疫系统与骨骼系统之间相互作用的跨学科研究，旨在揭示影响骨骼健康与疾病的免疫调节机制。衰老 是一个宏观概念，它不仅限于细胞衰老，还包括整个机体的衰老。研究表明，衰老可通过影响骨髓微环境、导致免疫细胞功能障碍、引发炎症反应和破坏骨稳态等多种机制影响骨免疫功能，进而导致骨疾病的发生。因此，本综述对骨免疫学的相关细胞和机制进行了全面介绍，详细阐述了免疫细胞和骨细胞衰老的特征、骨细胞与免疫细胞之间的相互影响以及衰老对骨免疫功能的影响。在此基础上，我们对急性髓系白血病、类风湿性关节炎、骨质疏松症和牙周炎中衰老及骨免疫发病机制提出了新见解，并提出了治疗骨免疫相关疾病的抗衰老策略，为骨免疫相关疾病的治疗提供了新思路。
