鸽饲养者病中的抗原：使用鸽粪抗原检测抗体活性。

Antigens in pigeon breeder's disease: the use of pigeon dropping antigens in detecting antibody activity.

作者信息

Tebo T H, Moore V L, Fink J N

出版信息

Clin Allergy. 1977 Mar;7(2):103-8. doi: 10.1111/j.1365-2222.1977.tb01430.x.

DOI:10.1111/j.1365-2222.1977.tb01430.x

Abstract

Sera from patients with pigeon breeder's disease were analysed for precipitating antibodies by immunodiffusion and immunoelectrophoresis using whole pigeon dropping extract (PDE) and a purified fraction of PDE (PDE1) as antigens. For comparison, sera from asymptomatic pigeon breeders and normal individuals were also tested for precipitating antibodies. Whereas whole PDE formed precipitin lines with normal serum as well as with serum from symptomatic and asymptomatic pigeon breeders, PDE1 formed precipitin lines only with serum from individuals exposed to pigeons, This suggests that whole PDE forms non-specific (non-antigen-antibody reactions) as well as specific precipitin lines, while PDE1 appears to form only specific lines. These data indicate that whole PDE has limited usefulness in studies of pigeon breeder's disease. It is also possible that PDE1 will be useful in studies of this disease.

摘要

采用全鸽粪提取物（PDE）和PDE纯化组分（PDE1）作为抗原，通过免疫扩散和免疫电泳分析养鸽者病患者血清中的沉淀抗体。为作比较，还检测了无症状养鸽者和正常个体血清中的沉淀抗体。全PDE与正常血清以及有症状和无症状养鸽者的血清均形成沉淀线，而PDE1仅与接触鸽子个体的血清形成沉淀线。这表明全PDE既形成非特异性（非抗原-抗体反应）沉淀线也形成特异性沉淀线，而PDE1似乎仅形成特异性沉淀线。这些数据表明全PDE在养鸽者病研究中的用途有限。PDE1也有可能在该疾病研究中发挥作用。