鸽饲养者病的抗原。II. 抗原PDE1的分离与特性鉴定
The antigens of pigeon breeder's disease. II. Isolation and characterization of antigen PDE1.
作者信息
Tebo T H, Fredricks W W, Roberts R C
出版信息
Int Arch Allergy Appl Immunol. 1977;54(6):553-9. doi: 10.1159/000231876.
PMID:885637
Abstract
Antigen PDE1 was purified from pigeon dropping extracts by chromatography on DEAE-cellulose and Bio-Gel A-1.5. It was characterized as a glycoprotein, containing 88% protein and 12% carbohydrate, with a molecular weight of approximately 200,000. PDE1 appears to be derived from pigeon intestinal IgA, showing the typical immunoglobulin structure of heavy and light chains. This antigen represents about 24% of the dry weight of the unfractionated pigeon dropping extract.
摘要
抗原PDE1通过在DEAE - 纤维素和Bio - Gel A - 1.5上进行色谱法从鸽粪提取物中纯化得到。它被鉴定为一种糖蛋白，含有88%的蛋白质和12%的碳水化合物，分子量约为200,000。PDE1似乎源自鸽肠道IgA，呈现出重链和轻链的典型免疫球蛋白结构。这种抗原约占未分级鸽粪提取物干重的24%。
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