Steen G, Axelsson H, Bowallius M, Holthuis N, Molander B M
Acta Neurol Scand. 1985 Sep;72(3):328-35. doi: 10.1111/j.1600-0404.1985.tb00879.x.
Recently discovered metabolites in urine have suggested a defect of isoprenoid metabolism in multiple sclerosis. Lymphocyte HMG-CoA reductase was found unaffected however, and so was lymphocyte biosynthesis of geraniol, farnesol and squalene from mevalonolactone. The level of dolichol in white matter of an MS brain was similar to that of a control sample. Serum ubiquinone, on the other hand, was decreased in multiple sclerosis. Ubiquinone in serum was both age-dependent and related to serum cholesterol. Active as well as stable MS displayed a decreased level of serum ubiquinone, and a reduced ubiquinone-cholesterol ratio. These results are compatible with a deficient ubiquinone biosynthesis in multiple sclerosis.
最近在尿液中发现的代谢物提示多发性硬化症中类异戊二烯代谢存在缺陷。然而，发现淋巴细胞HMG-CoA还原酶未受影响，从甲羟戊酸内酯合成香叶醇、法尼醇和角鲨烯的淋巴细胞生物合成也未受影响。多发性硬化症患者大脑白质中的多萜醇水平与对照样本相似。另一方面，多发性硬化症患者血清辅酶Q水平降低。血清中的辅酶Q既与年龄有关，也与血清胆固醇有关。活动期和稳定期的多发性硬化症患者血清辅酶Q水平均降低，辅酶Q-胆固醇比值也降低。这些结果与多发性硬化症中辅酶Q生物合成不足相符。
