Dirat M F, Valdiguie P
Clin Chim Acta. 1977 Jun 15;77(3):219-25. doi: 10.1016/0009-8981(77)90225-x.
Using single radial immunodiffusion, ten glycoproteins from non purulent pleural fluids have been estimated in different diseases. For five proteins (prealbumin, ceruloplasmin, alpha2HS-glycoprotein, transferrin, beta2-glycoprotein 1) the results have been found not to correlate with the causal disease. However for orosomucoid, alpha1-antitrypsin, haptoglobin, alpha2-macroglobulin and hemopexin, there was good correlation between proteins levels and aetiology. The glycoprotein concentration was low in mechanical effusions from cirrhosis and chronic cardiac failure. It was high in inflammatory, post-embolism and particularly neoplastic effusions. A raised orosomucoid level occurred as the most characteristic of cancer states especially when associated with a parallel increase of the four other glycoproteins. A simultaneously elevated level of these five pleural glycoproteins seems to be a good and significant biological sign for neoplastic effusion diagnosis.
采用单向放射免疫扩散法，对不同疾病患者非脓性胸腔积液中的十种糖蛋白进行了测定。结果发现，其中五种蛋白（前白蛋白、铜蓝蛋白、α2HS-糖蛋白、转铁蛋白、β2-糖蛋白1）的水平与致病疾病无关。然而，对于类黏蛋白、α1-抗胰蛋白酶、触珠蛋白、α2-巨球蛋白和血红素结合蛋白，蛋白水平与病因之间存在良好的相关性。肝硬化和慢性心力衰竭所致的机械性胸腔积液中糖蛋白浓度较低。炎症性、栓塞后尤其是肿瘤性胸腔积液中糖蛋白浓度较高。类黏蛋白水平升高是癌症状态最典型的特征，尤其是与其他四种糖蛋白水平同时升高时。这五种胸腔糖蛋白水平同时升高似乎是诊断肿瘤性胸腔积液的一个良好且显著的生物学指标。
