Kından Aykut, Kından Aziz, Kurt Ahmet, Akbulut Volkan Özgür, Dilbaz Berna
Department of Obstetrics and Gynecology, Pursaklar State Hospital, Mimar Sinan Mh. Çağatay Sk. No:39 , Pursaklar / ANKARA, 06145, Turkey.
Department of Perinatology, Etlik City Hospital, Ankara, Turkey.
BMC Womens Health. 2025 Jul 4;25(1):305. doi: 10.1186/s12905-025-03842-9.
This study aimed to investigate the effects of cyst volume and bilaterality on serum Anti-Müllerian Hormone (AMH) and CA-125 levels in patients with benign ovarian cysts.
We retrospectively analyzed 139 patients who underwent cystectomy for benign ovarian cysts. Serum AMH and CA-125 levels were measured preoperatively and at the second post-operative month.
The mean preoperative AMH level was 3.96 ± 3.48 ng/mL, which significantly decreased to 3.59 ± 3.92 ng/mL postoperatively (p = 0.026), reflecting an average decline of 9.3%. CA-125 levels significantly decreased from 53.1 ± 157.2 to 21.0 ± 18.4 U/mL (p = 0.002). Patients with bilateral cysts had lower AMH levels at the second month (1.67 ± 0.6 vs. 3.80 ± 4.1 ng/mL; p = 0.003) despite similar baseline values.
Bilaterality and cyst volume may negatively affect ovarian reserve postoperatively. The decline in AMH levels, particularly following bilateral ovarian cystectomy, has a significant impact on the ovarian reserve and may have implications for future fertility. Early fertility counselling and ovarian preservation strategies should be considered during surgical planning.
本研究旨在探讨囊肿体积和双侧性对良性卵巢囊肿患者血清抗苗勒管激素（AMH）和CA - 125水平的影响。
我们回顾性分析了139例行良性卵巢囊肿切除术的患者。术前及术后第二个月测量血清AMH和CA - 125水平。
术前平均AMH水平为3.96±3.48 ng/mL，术后显著降至3.59±3.92 ng/mL（p = 0.026），平均下降9.3%。CA - 125水平从53.1±157.2显著降至21.0±18.4 U/mL（p = 0.002）。双侧囊肿患者在第二个月时AMH水平较低（1.67±0.6 vs. 3.80±4.1 ng/mL；p = 0.003），尽管基线值相似。
双侧性和囊肿体积可能对术后卵巢储备产生负面影响。AMH水平的下降，尤其是双侧卵巢囊肿切除术后，对卵巢储备有显著影响，可能对未来生育产生影响。在手术规划过程中应考虑早期生育咨询和卵巢保留策略。
