Wang Elisa, Doig Gordon S, Ly Angelica
Centre for Eye Health, Rupert Myers Building, Gate 14 Barker Street, University of New South Wales, Sydney, NSW 2052, Australia.
School of Optometry and Vision Science, Rupert Myers Building, Gate 14 Barket Street, University of New South Wales, Sydney, NSW 2052, Australia.
Health Educ Res. 2025 Jun 26;40(4). doi: 10.1093/her/cyaf029.
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss worldwide. Appropriate care is available for patients, reducing the risk of AMD progression. Unfortunately, patients do not always receive appropriate eye care. Our study aimed to develop and evaluate an enhanced educational intervention focused on the health benefits expected from receiving appropriate eye care for AMD. We conducted a randomized, single-blind, controlled trial between May 2022 and October 2023 at an intermediate-tier not-for-profit clinic, the Centre for Eye Health. We recruited 137 patients previously diagnosed with intermediate or advanced (neovascular, geographic atrophy) AMD. Patients were enrolled and randomized (68 enhanced education, 69 standard care). On the intention-to-treat analysis, there was no significant difference between groups with regards to the primary outcome, confidence in the eye health benefits of AMD-related care at 6 months (P = .25). On a priori-defined subgroup analysis, enhanced education resulted in a clinically meaningful and statistically significant differential improvement in confidence in the eye health benefits of AMD-related care for patients who were diagnosed with AMD less than 5 years ago (Pinteraction = .036). Further study is needed to confirm whether enhanced education can improve confidence in eye health care benefits for newly diagnosed AMD patients. Trial registration: anzctr.org.au Identifier: ACTRN12622000984796.
年龄相关性黄斑变性（AMD）是全球不可逆视力丧失的主要原因。有适合患者的护理措施，可降低AMD进展的风险。不幸的是，患者并非总能获得适当的眼部护理。我们的研究旨在开发并评估一种强化教育干预措施，该措施聚焦于接受适当的AMD眼部护理所预期的健康益处。2022年5月至2023年10月，我们在一家中级非营利性诊所——眼健康中心进行了一项随机、单盲、对照试验。我们招募了137名先前被诊断为中度或重度（新生血管性、地图样萎缩）AMD的患者。患者被纳入研究并随机分组（68名接受强化教育，69名接受标准护理）。在意向性分析中，两组在主要结局方面没有显著差异，即6个月时对AMD相关护理的眼部健康益处的信心（P = 0.25）。在先验定义的亚组分析中，对于那些在不到5年前被诊断为AMD的患者，强化教育在对AMD相关护理的眼部健康益处的信心方面产生了具有临床意义且在统计学上有显著差异的改善（P交互作用 = 0.036）。需要进一步研究来确认强化教育是否能提高新诊断的AMD患者对眼部保健益处的信心。试验注册：anzctr.org.au 标识符：ACTRN12622000984796
