Maguire Emily, Winston Jincy, Ellwood Sarah H, O'Donoghue Rachel, Shaw Bethany, Morales Atahualpa Castillo, Keat Samuel, Evans Alexandra, Marshall Rachel, Luckcuck Lauren, Brown Laura, Salis Elisa, Leonenko Ganna, Denning Nicola, Allen Nicholas D, Escott-Price Valentina, Webber Caleb, Taylor Philip R, Sims Rebecca, Cowley Sally A, Williams Julie, Carpanini Sarah M, Hall-Roberts Hazel
UK Dementia Research Institute at Cardiff University, Maindy Road, CF24 4HQ Cardiff, UK.
James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK.
Stem Cell Reports. 2025 Aug 12;20(8):102570. doi: 10.1016/j.stemcr.2025.102570. Epub 2025 Jul 3.
Common forms of Alzheimer's disease (AD) are complex and polygenic. We have created a research resource that seeks to capture the extremes of polygenic risk in a collection of human induced pluripotent stem cell (iPSC) lines from over 100 donors: the IPMAR Resource (iPSC Platform to Model Alzheimer's Disease Risk). Donors were selected from a large UK cohort of 6,000+ research-diagnosed early or late-onset AD cases and elderly cognitively healthy controls, many of whom have lived through the age of risk for disease development (>85 years). We include iPSC with extremes of global AD polygenic risk (high-risk late-onset AD: 34; high-risk early-onset AD: 29; low-risk control: 27) as well as those reflecting complement pathway-specific genetic risk (high-risk AD: 9; low-risk controls: 10). All iPSC have associated clinical, longitudinal, and genetic datasets and will be available through collaboration or from cell (EBiSC) and data (DPUK) repositories.
常见形式的阿尔茨海默病（AD）是复杂的多基因疾病。我们创建了一个研究资源库，旨在从100多名捐赠者的人类诱导多能干细胞（iPSC）系集合中捕捉多基因风险的极端情况：IPMAR资源库（模拟阿尔茨海默病风险的iPSC平台）。捐赠者选自英国一个由6000多名经研究诊断为早发性或晚发性AD病例以及认知健康的老年对照组成的大型队列，其中许多人已度过疾病发展的风险年龄（>85岁）。我们纳入了具有全球AD多基因风险极端情况的iPSC（高风险晚发性AD：34个；高风险早发性AD：29个；低风险对照：27个）以及那些反映补体途径特异性遗传风险的iPSC（高风险AD：9个；低风险对照：10个）。所有iPSC都有相关的临床、纵向和遗传数据集，可通过合作或从细胞（EBiSC）和数据（DPUK）储存库获取。
