Lokka Georgia, Chantzara Anna, Lygerou Zoi, Taraviras Stavros
Department of Physiology, School of Medicine, University of Patras, Patras, Greece.
Department of General Biology, School of Medicine, University of Patras, Patras, Greece.
Stem Cell Reports. 2025 Sep 9;20(9):102574. doi: 10.1016/j.stemcr.2025.102574. Epub 2025 Jul 3.
Multiciliated ependymal and neural stem cells are key cell populations of the subventricular zone. Recent findings revealed that at least a subpopulation of radial glial cells during embryogenesis can be bipotent and produce both neural stem cells and ependymal cells. The balance between these cell populations is orchestrated by Geminin superfamily, ensuring optimal niche function. However, whether cell fate decisions are definitive or dynamic and whether potential regional differences exist remain elusive. In this review, we delve into the shared origins of different subventricular zone cell populations, and we explore the potential interplay among them. Moreover, we compile evidence on the de-differentiation capacity of ependymal cells and their controversial neural stem cell function under specific conditions, with emphasis on the possible implication of a rare population of biciliated (E2) ependymal cells. Understanding the mechanisms regulating cell fate decisions may unravel ependymal cells' therapeutic potential in therapies targeting various human diseases.
多纤毛室管膜细胞和神经干细胞是脑室下区的关键细胞群。最近的研究发现，胚胎发育过程中至少有一部分放射状胶质细胞具有双能性，能够产生神经干细胞和室管膜细胞。Geminin超家族协调这些细胞群之间的平衡，确保最佳的微环境功能。然而，细胞命运决定是确定的还是动态的，以及是否存在潜在的区域差异，仍然不清楚。在这篇综述中，我们深入探讨了不同脑室下区细胞群的共同起源，并探索了它们之间可能的相互作用。此外，我们收集了关于室管膜细胞去分化能力及其在特定条件下有争议的神经干细胞功能的证据，重点关注罕见的双纤毛（E2）室管膜细胞群的可能影响。了解调节细胞命运决定的机制可能会揭示室管膜细胞在针对各种人类疾病的治疗中的治疗潜力。
