Houghton P W, Jones D C
Gastroenterology. 1977 Aug;73(2):252-4.
We have developed a test system for the evaluation of gastric secretion in the rhesus monkey on a chronic basis that does not require the usual restraining techniques. The system is characterized by ease of animal maintenance and handling, reliability in introducing test substances into the stomach, and long term postsurgical stability. The system comprises a surgical preparation whereby the gastrostomy tube is inserted permanently in the stomach, is passed subcutaneously up the back, and is exteriorized at the top of the skull, and a training procedure that conditions the monkeys so as to facilitate easy handling during the administration of test substances and the collection of gastric controls. Values for pH, volume, total acid, and acid concentration appear reasonably consistent under base-line (no test substance) conditions as well as after the intragastric administration of water or the subcutaneous injection of Histalog.
我们开发了一种用于长期评估恒河猴胃分泌的测试系统，该系统不需要常用的约束技术。该系统的特点是易于饲养和处理动物、将测试物质引入胃中的可靠性以及术后长期稳定性。该系统包括一种外科手术准备，通过该准备将胃造瘘管永久插入胃中，经皮下向上穿过背部，并在颅骨顶部引出体外，以及一种训练程序，该程序对猴子进行训练，以便在给予测试物质和收集胃对照物时便于操作。在基线（无测试物质）条件下以及胃内给予水或皮下注射组胺后，pH值、体积、总酸和酸浓度的值似乎相当一致。
