Katake Ajay, Kumar Lalit, Singh Balbir, Haraniya Kruti, Vashistha Rajesh, Basandrai Deepak
Department of Physics, School of Chemical and Physical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Department of Radiation Oncology, N M Virani Wockhardt Hospital, Rajkot, Gujrat, India.
J Cancer Res Ther. 2025 Apr 1;21(3):678-685. doi: 10.4103/jcrt.jcrt_1816_24. Epub 2025 Jul 5.
The aim of the present study was to create an indigenous anthropomorphic heterogeneous female pelvis (AHFP) phantom for quality assurance and dosimetric audits in advance radiotherapy centers.
The AHFP phantom was designed using paraffin wax, epoxy, water, polyvinyl chloride (PVC), and a hardener. A dosimetric audit was conducted using the fabricated phantom among four different hospitals. The hospitals were instructed to perform the procedure of treatment planning and delivery as per their institutional protocol. Each institute was asked to make optimized plans using available intensity-modulated radiation therapy (IMRT) and rapid arc (RA) delivery technique. Apart from this, additional plans were generated for using single field (1F), double field (2F), three field (3F), and four field (4F) for 5 cm × 5 cm and 10 cm × 10 cm geometry, 3dimensional conformal radiotherapy (3F, 4F), and IMRT (5F, 7F and 9F).
With regard to the measured radiological properties, the mean Hounsfield units (HUs) were 87.3 ± 39.45, 1122.5 ± 270.1, 1312.2 ± 232.5, 10.1 ± 58.5, and 20.2 ± 33.8; the mean relative electron densities (REDs) were 1.087 ± 0.04, 1.673 ± 0.16, 1.765 ± 0.14, 1.010 ± 0.06, and 1.021 ± 0.03 g/cc and the mean mass densities (MDs) were 1.074 ± 0.03, 1.673 ± 0.15, 1.765 ± 0.16, 1.011 ± 0.06, and 1.021 ± 0.03 g/cc for soft tissue, femoral head, bones, rectum, and bladder of AHFP phantom, respectively. The percentage deviations between measured and computed doses were within ± 3% for all measurements performed under the study in each hospital.
The fabricated AHFP phantom mimics the size, shape, and radiological properties of female pelvis. The dosimetric results from participant hospitals were within prescribed tolerance. The present study confirms the efficacy of the AHFP phantom as a trustworthy quality assurance tool in radiotherapy. Hence, it can be used for end-to-end validation and dosimetric audit of advanced radiation therapy centers.
本研究的目的是制作一个本土的拟人化异质女性骨盆(AHFP)体模,用于放疗中心的质量保证和剂量学审核。
AHFP体模采用石蜡、环氧树脂、水、聚氯乙烯(PVC)和一种硬化剂设计而成。使用制作好的体模在四家不同医院进行了剂量学审核。指导这些医院按照其机构规程执行治疗计划和实施程序。要求每个机构使用可用的调强放射治疗(IMRT)和容积旋转调强放疗(RA)实施技术制定优化计划。除此之外,还针对5 cm×5 cm和10 cm×10 cm几何形状,分别生成了使用单野(1F)、双野(2F)、三野(3F)和四野(4F)的附加计划,以及三维适形放疗(3F、4F)和IMRT(5F、7F和9F)。
关于测量的放射学特性,AHFP体模的软组织、股骨头、骨骼、直肠和膀胱的平均Hounsfield单位(HU)分别为87.3±39.45、1122.5±270.1、1312.2±232.5、10.1±58.5和20.2±33.8;平均相对电子密度(RED)分别为1.087±0.04、1.673±0.16、1.765±0.14、1.010±0.06和1.021±0.03 g/cc,平均质量密度(MD)分别为1.074±0.03、1.673±0.15、1.765±0.16、1.011±0.06和1.021±0.03 g/cc。在本研究中每家医院进行的所有测量中,测量剂量与计算剂量之间的百分比偏差在±3%以内。
制作的AHFP体模模拟了女性骨盆的大小、形状和放射学特性。参与研究的医院的剂量学结果在规定的公差范围内。本研究证实了AHFP体模作为放疗中可靠的质量保证工具的有效性。因此,它可用于先进放疗中心的端到端验证和剂量学审核。