Yan Hongwei, Huang Baoyi, Huang Shile, Zhuang Yingyin, Chen Qiuxia, Lan Qinghui, Zhou Peiling, Peng Shiyu, Zhang Changzheng
Guangdong Provincial Key Laboratory of Development and Education for Special Needs Children & School of Educational Sciences, Lingnan Normal University, Zhanjiang, 524048, China.
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, China.
Sci Rep. 2025 Jul 5;15(1):24043. doi: 10.1038/s41598-025-09217-2.
Oxytocin (OXT) is associated with cardioprotective effects and shows to alleviate symptoms of post-traumatic stress disorder (PTSD). This study investigates blood pressure and electrocardiographic (ECG) parameters in anesthetized normal rats utilizing intravenous (iv) and intracerebroventricular (icv) administration of oxytocinergic agents. We also assessed the effects of cervical vagotomy on the cardiovascular responses to iv OXT. Furthermore, we compared the cardiovascular responses to iv OXT in PTSD model rats with those in normal controls. The mean arterial pressure (MAP), mean heart rate (HR) and the standard deviation of normal-to-normal intervals (SDNN, an indicator of HR variability) were measured and analyzed. Results showed that iv, rather than icv, administration of OXT led to a concentration-dependent increase in MAP, a decrease in HR, and an increase in the SDNN. Cervical vagotomy did not significantly alter the MAP responses but reduced cardiac activities (both HR and SDNN) during OXT stimulation. PTSD model rats exhibited higher baseline MAP and HR, but showed a diminished cardiovascular response to OXT compared to normal rats. These findings suggest that OXT induces distinct cardiovascular effects in normal versus PTSD model rats, underscoring the need to consider the cardiovascular implications of OXT in clinical applications.
催产素（OXT）具有心脏保护作用，并显示出可缓解创伤后应激障碍（PTSD）的症状。本研究利用静脉内（iv）和脑室内（icv）给予催产素能药物，研究麻醉正常大鼠的血压和心电图（ECG）参数。我们还评估了颈迷走神经切断术对静脉注射OXT后心血管反应的影响。此外，我们比较了PTSD模型大鼠和正常对照大鼠对静脉注射OXT的心血管反应。测量并分析了平均动脉压（MAP）、平均心率（HR）和正常心动周期间期标准差（SDNN，HR变异性指标）。结果表明，静脉注射而非脑室内注射OXT导致MAP呈浓度依赖性升高、HR降低以及SDNN升高。颈迷走神经切断术并未显著改变OXT刺激期间的MAP反应，但降低了心脏活动（HR和SDNN）。PTSD模型大鼠表现出更高的基线MAP和HR，但与正常大鼠相比，对OXT的心血管反应减弱。这些发现表明，OXT在正常大鼠和PTSD模型大鼠中诱导出不同的心血管效应，强调在临床应用中需要考虑OXT对心血管的影响。
