Sagona M A, Bruszer G, Pearson F, Mascoli C C, Serkes K
Ann Allergy. 1985 Nov;55(5):674-7.
Discolysis (chemonucleolysis) with chymopapain, the proteolytic enzyme, is currently being used in the treatment of herniated lumbar discs. Of the patients receiving treatment, approximately 1% experience an anaphylactic reaction. This reaction is thought to be mediated by IgE antibodies to chymopapain. Because of this, it may be possible to predict potential reactors using in vitro testing. In the current study, five out of seven patients who experienced allergic anaphylaxis during discolysis demonstrated high IgE serum levels to chymopapain before treatment.
使用蛋白水解酶木瓜凝乳蛋白酶进行椎间盘溶解术（化学髓核溶解术）目前正用于治疗腰椎间盘突出症。在接受治疗的患者中，约1%会发生过敏反应。这种反应被认为是由针对木瓜凝乳蛋白酶的IgE抗体介导的。因此，有可能通过体外检测来预测潜在的反应者。在当前的研究中，七名在椎间盘溶解术期间发生过敏性过敏反应的患者中有五名在治疗前显示出对木瓜凝乳蛋白酶的高IgE血清水平。
