Malone Xiaowei, Alhayek Bakr, Telleria Orlando, Garza Juan F
Internal Medicine, AdventHealth Tampa, Tampa, USA.
Oncology, Florida Cancer Specialists, Tampa, USA.
Cureus. 2025 Jun 4;17(6):e85342. doi: 10.7759/cureus.85342. eCollection 2025 Jun.
Tumor lysis syndrome (TLS) is an oncological emergency that can lead to acute kidney injury (AKI), cardiac arrhythmias, seizures, and death. TLS typically arises after initiation of chemotherapy. However, spontaneous TLS (STLS) can occur rarely. Here, we present the case of a 56-year-old male with HIV-associated stage IV diffuse large B-cell lymphoma, who presents with STLS with severe AKI. With hemodialysis, febuxostat, and dose-adjusted chemotherapy, successful resolution of metabolic derangements and return of his baseline kidney function was achieved. Our case aims to provide insight into when to initiate chemotherapy in STLS patients with severe AKI.
肿瘤溶解综合征（TLS）是一种肿瘤急症，可导致急性肾损伤（AKI）、心律失常、癫痫发作和死亡。TLS通常在化疗开始后出现。然而，自发性TLS（STLS）很少见。在此，我们报告一例56岁男性，患有HIV相关的IV期弥漫性大B细胞淋巴瘤，出现伴有严重AKI的STLS。通过血液透析、非布司他和调整剂量的化疗，成功纠正了代谢紊乱，其肾功能恢复至基线水平。我们的病例旨在为患有严重AKI的STLS患者何时开始化疗提供见解。
