Douvier J J, Vergeret J, Taytard A, Brottier E, Domblides P, Dubos F, Freour P
Ann Med Interne (Paris). 1985;136(5):416-8.
The authors report a case of pleuro-pulmonary fibrosis after 9 months of high dose bromocriptine therapy for the treatment of Parkinson's disease. When the drug was stopped there was a significant improvement of the clinical state with complete regression of chest pain and dyspnea of effort. The major inflammatory biological syndrome disappeared completely. Chest X-rays showed partial improvement with signs of pleural pneumonitis. The results of ventilatory and respiratory function tests stabilised. After one year follow-up, the causal relationship of this iatrogenic pathology has therefore been established. The initial diagnostic problems are stressed, particularly with respect to malignant disease (mesothelioma) when there has been exposure to asbestos, as in our case. The early stages must be carefully looked for so as to prevent fibrosing complications. The presence of immune complexes in our case could indicate immuno-allergic mechanism.
作者报告了一例在使用高剂量溴隐亭治疗帕金森病9个月后出现胸膜-肺纤维化的病例。停药后，临床状态显著改善，胸痛和劳力性呼吸困难完全消退。主要的炎症生物学综合征完全消失。胸部X线显示部分改善，有胸膜肺炎的迹象。通气和呼吸功能测试结果稳定。经过一年的随访，因此确定了这种医源性病理的因果关系。强调了最初的诊断问题，特别是在像我们病例中存在石棉暴露时关于恶性疾病（间皮瘤）的诊断问题。必须仔细寻找早期阶段，以预防纤维化并发症。我们病例中免疫复合物的存在可能表明免疫过敏机制。
