Song Shanshan, Yu Xina, Xie Changming, Li Zhanhua, Zhang Ying, Liu Yan, Qiu Zhongjue, Wang Tiantian, Su Hongna, Huang Hui, Luo Pei
State Key Laboratory for Quality Research in Chinese Medicines, Joint Laboratory of Guangdong-Hong Kong-Macao Universities for Internationalization of TCM, Macau University of Science and Technology, Macau 999078, China.
Guangxi Liuyao Group Company, Ltd., Liuzhou 545001, China.
J Agric Food Chem. 2025 Jul 23;73(29):18268-18279. doi: 10.1021/acs.jafc.5c01982. Epub 2025 Jul 7.
Panaxynol (PA), a bioactive compound found in carrots and other Apiaceae plants, holds promise for managing diabetes-related vascular complications. This study investigated the long-term effects of PA on diabetes-induced vascular calcification (DVC) in db/db mice for up to 9 weeks. The impact of PA on DVC was evaluated both in vivo and in vitro using immunohistochemical staining, Western blotting, micro-computed tomography, and other analytical techniques. Results demonstrated that PA significantly attenuated arterial calcification and collagen hyperplasia in the aorta. Additionally, PA elevated levels of the lipid signaling molecule 14,15-EET, which preserved the vascular structure and function by reducing inflammatory macrophage infiltration in perivascular adipose tissue. This protective effect was partially attributed to the PA-mediated inhibition of soluble epoxide hydrolase (sEH) through Sirt6 activation. These findings highlight PA as a potential natural therapeutic strategy for mitigating diabetic vascular complications and offer an alternative to conventional pharmacological approaches.
人参炔醇（PA）是一种在胡萝卜和其他伞形科植物中发现的生物活性化合物，有望用于治疗糖尿病相关的血管并发症。本研究调查了PA对db/db小鼠糖尿病诱导的血管钙化（DVC）长达9周的长期影响。使用免疫组织化学染色、蛋白质印迹法、微型计算机断层扫描和其他分析技术，在体内和体外评估了PA对DVC的影响。结果表明，PA显著减轻了主动脉的动脉钙化和胶原增生。此外，PA提高了脂质信号分子14,15-环氧二十碳三烯酸（14,15-EET）的水平，该分子通过减少血管周围脂肪组织中的炎性巨噬细胞浸润来维持血管结构和功能。这种保护作用部分归因于PA通过激活Sirt6介导的对可溶性环氧化物水解酶（sEH）的抑制。这些发现突出了PA作为减轻糖尿病血管并发症的潜在天然治疗策略，并为传统药理学方法提供了一种替代方案。
