Fody E P, Walker E M
Ann Clin Lab Sci. 1985 Nov-Dec;15(6):451-8.
Infertility, permanent or temporary, resulting from drug-induced injury is an important clinical problem. Many common used drugs are potentially toxic to gonads. It is well-known that estrogens are toxic to the male genital system, but androgens may also produce infertility. Anovulation may also be a consequence of exposure to sex steroids. Cimetidine regularly produces hypospermia in men; phenytoin does so occasionally. Marijuana has been shown to be a gonadal toxin, while the effects of lysergic acid diethylamide (LSD) remain controversial. The most significant group of drugs that may injure the gonads is the cancer chemotherapeutic agents, of which the alkylating agents are the worst offenders. Prediction of infertility induced by these agents may be possible based on the duration of therapy and the patient's age and sex.
药物性损伤导致的永久性或暂时性不孕是一个重要的临床问题。许多常用药物对性腺可能具有潜在毒性。众所周知，雌激素对男性生殖系统有毒性，但雄激素也可能导致不孕。接触性类固醇也可能导致无排卵。西咪替丁经常导致男性精子减少；苯妥英偶尔会导致这种情况。大麻已被证明是一种性腺毒素，而麦角酸二乙酰胺（LSD）的影响仍存在争议。最有可能损伤性腺的一类药物是癌症化疗药物，其中烷化剂是最严重的罪魁祸首。根据治疗持续时间、患者年龄和性别，有可能预测这些药物导致的不孕。
