Shi Jingwen, Xiao Weiling, Liu Yan, Fu Xiaoyan, Peng Meiyu
Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, Immunology Laboratory of Shandong Second Medical University, WeifangProvince, 261053, Shandong, China.
Department of Gynecology, Weifang People 's Hospital, Weifang, China.
Clin Transl Oncol. 2025 Jul 7. doi: 10.1007/s12094-025-03987-x.
Ovarian cancer is one of the most lethal cancers among gynecological tumors, with most cases diagnosed at an advanced stage. Despite advancements in medical science, current therapeutic options remain somewhat constrained, leading to a persistently high mortality among patients. The tumor microenvironment (TME) critically drives ovarian cancer progression by orchestrating tumorigenesis, metastasis, and chemoresistance via intercellular crosstalk, metabolic reprogramming, and immunosuppression. Tumor-associated macrophages (TAMs) and platelets are pivotal components of the ovarian cancer immune microenvironment. These components facilitate critical oncogenic processes, including tumor cell dissemination, immune evasion, and chemoresistance. Both TAMs and platelets have emerged as promising therapeutic targets. Furthermore, bidirectional crosstalk between platelets and TAMs dynamically shapes the immunosuppressive TME. This review synthesizes the roles and mechanisms of TAMs and platelets in ovarian cancer progression, discusses emerging therapeutic strategies targeting these components, and establishes a framework for advancing novel therapies in ovarian cancer treatment.
卵巢癌是妇科肿瘤中最致命的癌症之一，大多数病例在晚期才被诊断出来。尽管医学取得了进步，但目前的治疗选择仍然受到一定限制，导致患者死亡率持续居高不下。肿瘤微环境（TME）通过细胞间串扰、代谢重编程和免疫抑制来协调肿瘤发生、转移和化疗耐药性，从而严重推动卵巢癌的进展。肿瘤相关巨噬细胞（TAM）和血小板是卵巢癌免疫微环境的关键组成部分。这些成分促进关键的致癌过程，包括肿瘤细胞播散、免疫逃逸和化疗耐药性。TAM和血小板都已成为有前景的治疗靶点。此外，血小板和TAM之间的双向串扰动态塑造了免疫抑制性TME。本综述综合了TAM和血小板在卵巢癌进展中的作用和机制，讨论了针对这些成分的新兴治疗策略，并建立了推进卵巢癌治疗新疗法的框架。
