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Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum.移植相关病毒感染论坛:用于临床试验的移植患者中巨细胞病毒(CMV)感染和疾病(包括耐药和难治性 CMV)的共识定义:2024 年更新。
Clin Infect Dis. 2024 Sep 26;79(3):787-794. doi: 10.1093/cid/ciae321.
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Case Report: Cytomegalovirus-specific T-lymphocyte infusion for resistant cytomegalovirus retinitis.病例报告:巨细胞病毒特异性T淋巴细胞输注治疗耐药性巨细胞病毒性视网膜炎
Front Ophthalmol (Lausanne). 2023 Jul 3;3:1131674. doi: 10.3389/fopht.2023.1131674. eCollection 2023.
3
[Current status and progresses of cytomegalovirus infection management after hematopoietic stem cell transplantation in China].[中国造血干细胞移植后巨细胞病毒感染管理的现状与进展]
Zhonghua Nei Ke Za Zhi. 2024 Feb 1;63(2):217-224. doi: 10.3760/cma.j.cn112138-20230811-00045.
4
Adoptive therapy with cytomegalovirus-specific cytotoxic T lymphocytes for refractory cytomegalovirus DNAemia and disease after allogeneic haematopoietic stem cell transplantation.异基因造血干细胞移植后难治性巨细胞病毒血症和疾病的细胞巨化病毒特异性细胞毒性 T 淋巴细胞过继治疗。
Br J Haematol. 2024 Apr;204(4):1393-1401. doi: 10.1111/bjh.19282. Epub 2024 Jan 2.
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J Clin Microbiol. 2023 Dec 19;61(12):e0082923. doi: 10.1128/jcm.00829-23. Epub 2023 Nov 21.
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Treatment for First Cytomegalovirus Infection Post-Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir.在 AURORA 试验中造血细胞移植后首次巨细胞病毒感染的治疗:一项比较马拉韦罗与缬更昔洛韦的多中心、双盲、随机、3 期临床试验。
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《免疫功能低下人群难治性/耐药性巨细胞病毒感染诊断与治疗策略中国专家共识(2025年版)》

[Chinese expert consensus on the diagnosis and treatment strategies for refractory/resistant cytomegalovirus infection in immunocompromised populations (2025)].

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2025 May 14;46(5):402-409. doi: 10.3760/cma.j.cn121090-20250112-00024.

DOI:10.3760/cma.j.cn121090-20250112-00024
PMID:40623898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12268285/
Abstract

The number of immunocompromised individuals in China is rapidly increasing, and the incidence of cytomegalovirus (CMV) infection in this population is significantly higher than in the general population, severely affecting their quality of life and prognosis. Currently, a standardized diagnostic and treatment system for refractory/resistant CMV infections in immunocompromised populations is lacking. Based on domestic and international data on the epidemiology, evidence-based medicine, and clinical research regarding refractory/resistant CMV infections, this consensus formulates recommendations for the diagnosis, treatment, and management of these infections.

摘要

中国免疫功能低下人群的数量正在迅速增加,该人群中巨细胞病毒(CMV)感染的发生率显著高于普通人群,严重影响他们的生活质量和预后。目前,免疫功能低下人群难治性/耐药性CMV感染缺乏标准化的诊断和治疗体系。基于国内外关于难治性/耐药性CMV感染的流行病学、循证医学及临床研究数据,本共识制定了这些感染的诊断、治疗及管理建议。