Al Mohrij Saud S, Ghobara Yasser A, Al-Issa Ahmed
College of Medicine, Almaarefa University, Riyadh, SAU.
Dermatology, Derma Clinic, Riyadh, SAU.
Cureus. 2025 Jun 6;17(6):e85490. doi: 10.7759/cureus.85490. eCollection 2025 Jun.
Fox-Fordyce disease (FFD) is a rare, chronic skin disorder affecting apocrine sweat glands, predominantly in women. It manifests as pruritic, dome-shaped papules in areas such as the axillae and pubic region. Treatment remains challenging, with limited success from conventional therapies. We report two cases of Saudi women aged 27 and 28 years presenting with hyperpigmented axillary papules and mild pruritus, consistent with FFD. One patient had no comorbidities, while the other had a known history of sickle cell anemia. Both cases were managed with laser therapy (erbium:yttrium aluminum garnet (YAG) in case 1 and ablative CO₂ in case 2) using precise protocols and follow-up plans. Clinical images demonstrated visual improvement post treatment. Adjunctive topical therapy was administered to manage inflammation and prevent hyperpigmentation. The cases underscore the typical presentation of FFD and the potential efficacy of laser-based interventions, even in patients with complex medical histories. Notably, the presence of sickle cell anemia did not exacerbate FFD manifestations, supporting the current treatment modalities. While hormonal therapy was not employed, its relevance remains a subject for future exploration. Laser therapy offers a promising approach for managing refractory FFD. Further studies are warranted to evaluate long-term outcomes and explore hormone-modulating strategies tailored to FFD's pathophysiology.
福克斯-福代斯病（FFD）是一种罕见的慢性皮肤病，主要影响顶泌汗腺，多见于女性。其表现为腋窝和耻骨区等部位出现瘙痒性圆顶状丘疹。治疗仍然具有挑战性，传统疗法的成功率有限。我们报告了两例27岁和28岁的沙特女性病例，她们表现为腋窝色素沉着丘疹和轻度瘙痒，符合福克斯-福代斯病。一名患者无合并症，另一名患者有镰状细胞贫血病史。两例均采用激光治疗（病例1使用铒：钇铝石榴石（YAG）激光，病例2使用剥脱性二氧化碳激光），采用精确的方案和随访计划。临床图像显示治疗后有视觉改善。给予辅助局部治疗以控制炎症并预防色素沉着。这些病例强调了福克斯-福代斯病的典型表现以及基于激光干预的潜在疗效，即使是在有复杂病史的患者中。值得注意的是，镰状细胞贫血的存在并未加重福克斯-福代斯病的表现，支持了当前的治疗方式。虽然未采用激素治疗，但其相关性仍是未来探索的课题。激光治疗为难治性福克斯-福代斯病的管理提供了一种有前景的方法。有必要进一步研究以评估长期疗效，并探索针对福克斯-福代斯病病理生理学的激素调节策略。
