Qayyum Muhammad Abdul, Mahmood Mian H R, Farooq Tahir, Irfan Ahmad, Iqbal Shahid, Hussain Nazim
Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan.
Department of Applied Chemistry, Government College University, Faisalabad, 38000 Pakistan.
Indian J Clin Biochem. 2025 Jul;40(3):392-411. doi: 10.1007/s12291-024-01209-9. Epub 2024 Mar 25.
The prostate gland diseases are associated with benign prostatic hyperplasia (BPH) and prostate cancer (PC) and exposure to toxic trace elements may promote the prostatic disorders in men. The present study is intended to analyze the concentrations of twenty elements (Al, Sb, Ca, Se, Cd, Fe, Hg, As, Zn, Mn, Na, Li, Cu, Co, Mg, Sr, Ni, K, Cr and Pb) in the serum of BPH ( = 188) and PC ( = 217) patients and in comparison with controls ( = 233). Nitric acid-perchloric acid mixture was used for serum digestion followed by determination of the metals/metalloid by atomic absorption spectrophotometry. This study elucidates the imbalances of the elements with BPH/PC patients and healthy subjects. For multiple comparisons, Bonferroni test was applied and principal component analysis was performed for measuring the multiple metals/metalloid exposure. Mean concentrations of Al, Cr, Pb, Cd, Na, Ni and K were found higher significantly ( < 0.05) in the serum of BPH patients compared with healthy controls, while average levels of Sb, Al, Cd, As, Mn, Sr, K and Pb were significantly ( < 0.05) elevated in PC patients than controls. The correlation patterns revealed significantly different mutual associations among the metals/metalloid in patients as compared to controls. Multivariate statistical methods showed substantially divergent grouping of the metals/metalloid for both groups of patients and healthy controls. Significant variations in the elements levels were also detected in various PC types (small cell prostate, transitional cell, squamous cell carcinomas and adenocarcinoma) and PC stages. Significant differences in the metals/metalloid levels were also noted with abode, dietary and smoking habits of donor groups.
The online version contains supplementary material available at 10.1007/s12291-024-01209-9.
前列腺疾病与良性前列腺增生（BPH）和前列腺癌（PC）相关，接触有毒微量元素可能会促使男性出现前列腺疾病。本研究旨在分析188例BPH患者、217例PC患者以及233例对照者血清中20种元素（铝、锑、钙、硒、镉、铁、汞、砷、锌、锰、钠、锂、铜、钴、镁、锶、镍、钾、铬和铅）的浓度。采用硝酸-高氯酸混合液进行血清消解，然后用原子吸收分光光度法测定金属/类金属元素。本研究阐明了BPH/PC患者与健康受试者体内元素的失衡情况。对于多重比较，应用了Bonferroni检验，并进行主成分分析以测量多种金属/类金属元素的暴露情况。结果发现，与健康对照组相比，BPH患者血清中铝、铬、铅、镉、钠、镍和钾的平均浓度显著更高（P<0.05）；而与对照组相比，PC患者血清中锑、铝、镉、砷、锰、锶、钾和铅的平均水平显著升高（P<0.05）。相关性模式显示，与对照组相比，患者体内金属/类金属元素之间的相互关联存在显著差异。多变量统计方法表明，两组患者和健康对照组的金属/类金属元素分组存在明显差异。在不同的PC类型（小细胞前列腺癌、移行细胞癌、鳞状细胞癌和腺癌）和PC分期中也检测到元素水平的显著变化。供体组的居住地址、饮食习惯和吸烟习惯在金属/类金属元素水平上也存在显著差异。
在线版本包含可在10.1007/s12291-024-01209-9获取的补充材料。
