So Eiichiro, Ishida Norihito, Chida Akihiko, Horie Sara, Kishimoto Shotaro, Tsugaru Kai, Hayashi Hideyuki, Koda Yuya, Ozaki Masahiro, Okita Hajime, Kanai Takanori, Hirata Kenro
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.
Int Cancer Conf J. 2025 Jun 3;14(3):327-334. doi: 10.1007/s13691-025-00776-9. eCollection 2025 Jul.
Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a recently classified rare subtype of histiocytic neoplasm, characterized by ALK immunoreactivity due to gene rearrangement. Most reported cases have developed in infants and middle-aged individuals, with effective ALK inhibition. The clinicopathological spectrum remains uncharacterized because of few reported cases. Herein, we report a case of a 70-year-old woman diagnosed with ALK-positive histiocytosis involving the nervous system, successfully treated with partial surgical resection and alectinib administration. To the best of our knowledge, this is the oldest patient reported with this condition with nervous system involvement, expanding our understanding of its clinicopathological spectrum.
间变性淋巴瘤激酶（ALK）阳性组织细胞增多症是一种最近分类的罕见组织细胞肿瘤亚型，其特征是由于基因重排导致ALK免疫反应性。大多数报道的病例发生在婴儿和中年个体中，对ALK抑制有效。由于报道的病例较少，其临床病理谱仍未明确。在此，我们报告一例70岁女性被诊断为ALK阳性组织细胞增多症累及神经系统，经部分手术切除和给予阿来替尼成功治疗。据我们所知，这是报道的患有这种累及神经系统疾病的最年长患者，扩展了我们对其临床病理谱的认识。
