Verboven Kenneth, Van Ryckeghem Lisa, Schweiggert Ralf, Steingass Christof B, Gojevic Tin, Ruxton Carrie H S, Hansen Dominique
BIOMED Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
REVAL Rehabilitation Research Center, Hasselt University, Hasselt, Belgium.
Nutr Diabetes. 2025 Jul 9;15(1):31. doi: 10.1038/s41387-025-00385-8.
BACKGROUND/OBJECTIVES: Sugar-sweetened beverages are associated with an increased risk of obesity and type 2 diabetes (T2DM) and show clear differential metabolic responses compared with 100% fruit juice, which is unsweetened by law. This study investigated whether the postprandial glycaemic response following a standardized breakfast differed when accompanied by 100% orange juice, equivalent whole orange, or a sugar-sweetened control beverage in individuals with well-controlled T2DM.
SUBJECTS/METHODS: Fifteen individuals with T2DM (60 ± 6 y; BMI 28.7 ± 5.0 kg/m², HbA1C 49 ± 3 mmol/mol (6.6 ± 0.3%)) participated in this randomized cross-over trial. They consumed a standardized breakfast served with either 250 mL of 100% orange juice, a sugar-sweetened orange-flavoured beverage or whole orange pieces with identical total sugar content. Postprandial glycaemic and insulinaemic responses were checked during 4 h.
Following a single intake, no significant differences were found in acute glucose or insulin responses (expressed as total or incremental area under the curve or peak values; p > 0.05, respectively) when either whole orange pieces, orange juice or a sugar-sweetened control beverage were consumed with a standard high carbohydrate meal. Capillary glucose responses did not differ between conditions (p > 0.05).
Acute glycaemic control in individuals with well-controlled T2DM is not significantly influenced by serving orange juice, whole orange pieces or a sugar-sweetened beverage with a standard high-carbohydrate meal.
背景/目的：含糖饮料与肥胖和2型糖尿病（T2DM）风险增加相关，并且与依法未加糖的100%果汁相比，显示出明显不同的代谢反应。本研究调查了在T2DM控制良好的个体中，标准化早餐搭配100%橙汁、等量的完整橙子或含糖对照饮料时，餐后血糖反应是否存在差异。
受试者/方法：15名T2DM患者（60±6岁；体重指数28.7±5.0kg/m²，糖化血红蛋白49±3mmol/mol（6.6±0.3%））参与了这项随机交叉试验。他们食用了一份标准化早餐，搭配250mL的100%橙汁、一种含糖的橙子味饮料或总糖含量相同的完整橙子片。在4小时内检查餐后血糖和胰岛素反应。
单次摄入后，当完整橙子片、橙汁或含糖对照饮料与标准高碳水化合物餐一起食用时，急性葡萄糖或胰岛素反应（以曲线下总面积或增量面积或峰值表示；p分别>0.05）没有显著差异。不同条件下毛细血管血糖反应没有差异（p>0.05）。
T2DM控制良好的个体，急性血糖控制不会受到标准高碳水化合物餐搭配橙汁、完整橙子片或含糖饮料的显著影响。
