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一种新型血管支架及插入物概念,旨在改善血流动力学并维护血管健康。

A novel vascular stent and insert concept to improve hemodynamics and support vascular health.

作者信息

Vaziri Bahram, Zirak Saadat, Azadi Mohammad, Keshmiri Amir, Shokri Nima

机构信息

Faculty of Mechanical Engineering, Semnan University, Semnan, Iran.

School of Engineering, The University of Manchester, Manchester, UK.

出版信息

Sci Rep. 2025 Jul 8;15(1):24487. doi: 10.1038/s41598-025-09613-8.

Abstract

Obstruction of vessels is one of the most common health issues in the world and various methods of treatments have been offered, including medication therapy, stenting, and bypass surgery. However, recurrence of blockage is a major issue facing patients. The present work assesses the performance of a new innovative design of stents featuring two spirals, called 'inserts', which will create a rotating flow inside the vessel. Three different cases of artery and bypass configurations were studied and the results showed that the stent and inserts increased the axial and secondary velocity significantly. At a plane located 1 mm after anastomosis and at t = 0.25 s, the axial velocity was 23% higher for a case with stent and insert compared to the baseline configuration i.e., without stent/insert. In addition, it was found that the presence of the insert increases the wall shear stress (WSS). The maximum WSS among the three cases reached 113 Pa, which was 94% higher than the baseline case. The findings highlight the potential of the proposed stent/insert design in improving the hemodynamic parameters in the graft, anastomosis region, and the host artery, which in turn, could enhance the patency and longevity of the bypass graft.

摘要

血管阻塞是世界上最常见的健康问题之一,人们已经提供了各种治疗方法,包括药物治疗、支架置入和搭桥手术。然而,堵塞的复发是患者面临的一个主要问题。目前的工作评估了一种新型创新设计的支架的性能,该支架具有两个螺旋结构,称为“插入物”,它将在血管内产生旋转流。研究了三种不同的动脉和搭桥配置情况,结果表明,支架和插入物显著提高了轴向速度和二次速度。在吻合口后1毫米处的平面和t = 0.25秒时,与基线配置(即无支架/插入物)相比,有支架和插入物的情况下轴向速度高23%。此外,还发现插入物的存在增加了壁面剪应力(WSS)。三种情况中的最大WSS达到113帕,比基线情况高94%。这些发现突出了所提出的支架/插入物设计在改善移植物、吻合区域和宿主动脉中的血流动力学参数方面的潜力,这反过来又可以提高搭桥移植物的通畅性和寿命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9772/12238337/30e4b9a64286/41598_2025_9613_Fig1_HTML.jpg

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