Zhu Xuanyan, Chen Yun, Jiang Zhongyi, Bi Ran, Zhang Qiaoyang, Chen Yanli, Jiang Yupeng, Cao Yin, Dong Guanzhong
Department of Psychology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.
School of Computer and Artificial Intelligence, Changzhou University, Changzhou, China.
BMC Psychol. 2025 Jul 8;13(1):751. doi: 10.1186/s40359-025-03065-5.
The role of non-suicidal self-injury (NSSI) in the suicide process of people with major depressive disorder(MDD) remains controversial. Therefore, the purpose of this study was to investigate the role NSSI plays in suicide risk in people with MDD.
A questionnaire survey was compiled using the Hamilton Depression Scale-24, the Baker Suicide Risk Scale, and the Deliberate self-harm Scale. The correlation between NSSI, depression, and suicide risk was analyzed using the gradient-lifting regression model.
A total of 179 people with MDD aged 15-24 years were included in this study. NSSI had the highest incidence among high school students(63.3%), regardless of sex. Furthermore, the incidence of NSSI was high among patients with depression with a history of smoking(p < 0.0002) and drinking(p < 0.001). NSSI partially mediated the risk of suicide in people with depression.
The findings demonstrate a significant association between NSSI and elevated suicide risk scores in individuals with MDD, with NSSI acting as a partial mediator in this relationship.
非自杀性自伤（NSSI）在重度抑郁症（MDD）患者自杀过程中的作用仍存在争议。因此，本研究旨在探讨NSSI在MDD患者自杀风险中所起的作用。
使用汉密尔顿抑郁量表-24、贝克自杀风险量表和故意自伤量表编制问卷调查。采用梯度提升回归模型分析NSSI、抑郁和自杀风险之间的相关性。
本研究共纳入179例年龄在15至24岁之间的MDD患者。无论性别，NSSI在高中生中发病率最高（63.3%）。此外，有吸烟史（p<0.0002）和饮酒史（p<0.001）的抑郁症患者中NSSI的发病率较高。NSSI部分介导了抑郁症患者的自杀风险。
研究结果表明，NSSI与MDD患者自杀风险评分升高之间存在显著关联，NSSI在这种关系中起部分中介作用。
