Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium.
Psychiatry Res Neuroimaging. 2023 Dec;336. doi: 10.1016/j.pscychresns.2023.111725. Epub 2023 Oct 20.
The structural neural correlates underlying youth nonsuicidal self-injury (NSSI) warrant further exploration. Few studies have explored the association between NSSI and brain structure in adolescence, and no studies have investigated differences in the relation between age and brain structure in youth with NSSI. This preliminary investigation examined associations between NSSI history, age, and cortical structure using magnetic resonance imaging in adolescent girls (=100, =13.4 years) at increased risk for psychopathology. We conducted whole-brain analyses to investigate the associations between age and cortical structure, NSSI history and cortical structure, and NSSI history as a moderator of the association between age and cortical structure. Results suggested that age was associated with less cortical thickness and surface area in the left and right prefrontal, temporal, and parietal cortex. NSSI history was associated with less left insula and left inferior parietal cortex cortical surface area. Among adolescents with NSSI history, older age predicted greater left inferior parietal cortex surface area and was not associated with left precentral cortex surface area. Among adolescents without NSSI history, older age predicted smaller surface areas as expected with the typical trajectory of neurodevelopment. Overall, our results suggest differences in cortical surface area development in adolescents with NSSI history.
青年非自杀性自伤（NSSI）的结构神经相关性值得进一步探讨。很少有研究探讨 NSSI 与青少年大脑结构之间的关联，也没有研究调查 NSSI 青少年中年龄与大脑结构之间关系的差异。本初步研究使用磁共振成像（MRI）检查了处于心理病理风险增加的青春期女孩（n=100，年龄=13.4 岁）的 NSSI 史、年龄与皮质结构之间的关联。我们进行了全脑分析，以调查年龄与皮质结构、NSSI 史与皮质结构之间的关联，以及 NSSI 史作为年龄与皮质结构之间关联的调节剂的作用。结果表明，年龄与左、右前额叶、颞叶和顶叶皮质的皮质厚度和表面积减少有关。NSSI 史与左侧岛叶和左侧顶下皮质表面积减少有关。在有 NSSI 史的青少年中，年龄较大与左侧顶下皮质表面积增加有关，而与左侧中央前回表面积无关。在没有 NSSI 史的青少年中，年龄较大与预期的典型神经发育轨迹一致，与表面积减少有关。总体而言，我们的结果表明，有 NSSI 史的青少年的皮质表面积发育存在差异。
