Shin Woo Jin, Min Young Ki, Kim Dae Yeung, Kim Tae Hyung, Moon Sung Jun, Yi Jin Woong, Kim Tae Gyun, Jang Min Gu, Song Jae Hwang
Department of Orthopaedic Surgery, Konyang University Hospital, Daejeon, Republic of Korea.
Medicine (Baltimore). 2025 Jul 4;104(27):e43209. doi: 10.1097/MD.0000000000043209.
To date, no consensus has been reached regarding the efficacy or duration of postoperative oral antibiotics after foot and ankle surgery. The purpose of the present study was to compare the effects of single- and multiday prophylactic use of postoperative oral antibiotics in foot and ankle bone surgery using inflammatory biomarkers. In total, 64 patients who underwent foot and ankle bone surgery at our institution were divided into multiday (n = 43) and single-day (n = 21) postoperative oral antibiotics groups. Demographic characteristics, diagnosis, and type of surgery were recorded. Surgical site infection and inflammatory biomarkers including the white blood cell count, erythrocyte sedimentation rate, and C-reactive protein level were evaluated pre- and postoperatively. There was no case of surgical site infection or other complications with single- and multiday oral antibiotic prophylaxis among patients undergoing foot and ankle bone surgery. The single-day postoperative oral antibiotics group had a significantly shorter antibiotic duration compared with the multiday group (P < .001). Regarding inflammatory biomarkers, there were no significant between-group differences in the pre- or postoperative white blood cell count, erythrocyte sedimentation rate, or C-reactive protein level (P > .05). In conclusion, single-day oral antibiotic prophylaxis in patients undergoing foot and ankle bone surgery showed favorable outcomes. There were no significant differences in inflammatory biomarker levels between the single- and multiday oral antibiotic prophylaxis groups.
迄今为止，关于足踝手术后口服抗生素的疗效或持续时间尚未达成共识。本研究的目的是使用炎症生物标志物比较足踝骨手术中术后口服抗生素单日预防性使用和多日预防性使用的效果。共有64例在我院接受足踝骨手术的患者被分为术后口服抗生素多日组（n = 43）和单日组（n = 21）。记录人口统计学特征、诊断和手术类型。在术前和术后评估手术部位感染以及炎症生物标志物，包括白细胞计数、红细胞沉降率和C反应蛋白水平。在接受足踝骨手术的患者中，单日和多日口服抗生素预防均未出现手术部位感染或其他并发症的情况。与多日组相比，术后口服抗生素单日组的抗生素使用持续时间明显更短（P < .001）。关于炎症生物标志物，术前或术后白细胞计数、红细胞沉降率或C反应蛋白水平在组间无显著差异（P > .05）。总之，足踝骨手术患者术后单日口服抗生素预防显示出良好的效果。单日和多日口服抗生素预防组之间的炎症生物标志物水平无显著差异。
