Aderinto Nicholas, Olatunji Gbolahan, Kokori Emmanuel, Olatunji Doyin, Omoworare Oluwatobi, Babalola Adetola Emmanuel, Ezeano Chimezirim, Olusanya Damilare Adewale, Isarinade David Timilehin, Akinoso Aminat, Akinboade Adeola, Moradeyo Abdulrahmon, Nkrumah-Ababio Naana
Department of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Department of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
Medicine (Baltimore). 2025 Jul 4;104(27):e43071. doi: 10.1097/MD.0000000000043071.
Gliomas pose significant therapeutic challenges due to limited survival and risks of treatment-related toxicity. Proton beam therapy (PBT) offers a precise radiation delivery method, minimizing damage to healthy brain tissue compared to conventional radiotherapy. This review synthesizes findings from 15 studies (2000-January 2024) from PubMed, Google Scholar, Science Direct, Cochrane Library, and Directory of Open Access Journals. PBT significantly reduces neurocognitive decline and enhances quality of life while achieving comparable or superior survival outcomes across various glioma types, including low-grade gliomas and glioblastomas. Notable benefits include improved verbal memory, stable intellectual functioning, and reduced high-grade toxicity. However, challenges such as neuroendocrine deficiencies and increased radiation necrosis highlight the need for optimized protocols. Future research should focus on comprehensive outcome assessments, proactive management of adverse effects, and improving PBT accessibility through cost reduction and technological advancements. PBT holds transformative potential in glioma management, balancing effective tumor control with preservation of neurological function, positioning it as a valuable neuro-oncology treatment option.
由于生存期有限以及存在治疗相关毒性风险，胶质瘤带来了重大的治疗挑战。质子束治疗（PBT）提供了一种精确的放射治疗方法，与传统放疗相比，可将对健康脑组织的损伤降至最低。本综述综合了来自PubMed、谷歌学术、科学Direct、Cochrane图书馆和开放获取期刊目录的15项研究（2000年 - 2024年1月）的结果。PBT显著减少神经认知功能下降并提高生活质量，同时在包括低级别胶质瘤和胶质母细胞瘤在内的各种胶质瘤类型中实现了相当或更好的生存结果。显著的益处包括改善言语记忆、稳定智力功能以及降低高级别毒性。然而，神经内分泌缺陷和放射性坏死增加等挑战凸显了优化方案的必要性。未来的研究应专注于全面的结果评估、积极管理不良反应以及通过降低成本和技术进步提高PBT的可及性。PBT在胶质瘤管理中具有变革潜力，在有效控制肿瘤与保留神经功能之间取得平衡，使其成为一种有价值的神经肿瘤治疗选择。
