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用于乳腺癌骨转移的水凝胶基材料研究进展：从靶向药物递送到骨微环境重塑

Advances in hydrogel-based materials for breast cancer bone metastasis: from targeted drug delivery to bone microenvironment remodeling.

作者信息

Chen Jiayi, Ma Jun, Xu Zhuoming, Luo Huanhuan, Qian Chenhong

机构信息

Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.

出版信息

Front Pharmacol. 2025 Jun 24;16:1627883. doi: 10.3389/fphar.2025.1627883. eCollection 2025.

DOI:10.3389/fphar.2025.1627883
PMID:40630133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12235189/
Abstract

Breast cancer has become the most common malignant tumor in women around the world, and bones are the most common part of all metastatic breast cancers. Breast cancer bone metastasis (BCBM) is the main cause of death in patients with advanced breast cancer. It is still mainly clinically palliative treatment, with problems such as systemic toxicity, low target specificity, and insufficient bone repair. Therefore, there is an urgent need to develop new therapeutic strategies to overcome these challenges. This review summarizes recent advances and innovative applications of smart hydrogel-based delivery systems for breast cancer bone metastasis, highlighting their significant potential in gene delivery and immune microenvironment remodeling. Current limitations and future research directions are also discussed.

摘要

乳腺癌已成为全球女性中最常见的恶性肿瘤，而骨骼是所有转移性乳腺癌最常见的转移部位。乳腺癌骨转移（BCBM）是晚期乳腺癌患者死亡的主要原因。目前临床上仍以姑息治疗为主，存在全身毒性、靶向特异性低和骨修复不足等问题。因此，迫切需要开发新的治疗策略来克服这些挑战。本文综述了基于智能水凝胶的递送系统在乳腺癌骨转移治疗中的最新进展和创新应用，强调了其在基因递送和免疫微环境重塑方面的巨大潜力。同时也讨论了当前的局限性和未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/a27562444d37/fphar-16-1627883-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/105c68246bb8/FPHAR_fphar-2025-1627883_wc_sch1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/d6ed4d1c1db9/fphar-16-1627883-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/7d5be9e6b5a4/fphar-16-1627883-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/96b94cad3e06/fphar-16-1627883-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/b32584cdb20f/fphar-16-1627883-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/34e2d6b0bbc7/fphar-16-1627883-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/a27562444d37/fphar-16-1627883-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/105c68246bb8/FPHAR_fphar-2025-1627883_wc_sch1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/45fd25421c9f/fphar-16-1627883-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/8ea211c81294/fphar-16-1627883-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/8940b2f0e4b1/fphar-16-1627883-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/6a052bf3d94b/fphar-16-1627883-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/d3d5645656e3/fphar-16-1627883-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/efbffa3dce39/fphar-16-1627883-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/d6ed4d1c1db9/fphar-16-1627883-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/7d5be9e6b5a4/fphar-16-1627883-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/96b94cad3e06/fphar-16-1627883-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/b32584cdb20f/fphar-16-1627883-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/34e2d6b0bbc7/fphar-16-1627883-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2b0/12235189/a27562444d37/fphar-16-1627883-g012.jpg

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本文引用的文献

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Advanced therapy medicinal products development - from guidelines to medicines in the market.先进治疗药品的研发——从指南到上市药品
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Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread.理解并逆转乳腺肿瘤驱动的髓系造血重编程以减少转移扩散。
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一种用于沉积基因和细胞制剂以促进协同癌症免疫治疗的可植入双层球形支架
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