Li Rourou, Zhang Guanjun, Yu Shuyan, Deng Ruyv, Yin Jiechun, Zhang Taijun, He Qiuxing
School of Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China.
Technical Support Department, Emperor's Wisdom Skin and Biotechnology Institute, Guangzhou, China.
Front Chem. 2025 Jun 24;13:1563560. doi: 10.3389/fchem.2025.1563560. eCollection 2025.
This investigation systematically elucidates the foam dynamics and consumer perception correlations within amino-acid-derived surfactant-mixedcomponent systems.
pH-gradient experiments (5.5-10) combined with dynamic foam analysis were employed to quantify foam nucleation kinetics. Molecular dynamics simulations analyzed intermolecular interactions, while lipid resistance evaluations measured cleaning efficiency.
SLG-CAB blends accelerated foam nucleation from 35 s to 20 s/100 mL (pH=8.5), outperforming commercial benchmarks (<5 s initial formation) with statistical significance. Robust hydrogen bonds between CAB's ammonium protons and SLG's carboxamide oxygen (bond length: 1.901 Å) achieved thermodynamic stabilization (ΔE = -53.04 kcal/mol), enhancing film stability (Tfls 50% > 5 min). SLG-CAB generated monodisperse bubbles (diameter ≈95 μm), imparting "velvety" sensory properties, with 74.74% lipid cleaning efficiency at pH 7-8 (synergistic coefficient βs = -2.822).
The SLG-CAB system demonstrates synergistic foam enhancement and lipid resistance, enabling "prolonged creaminess" in cleansing applications. Bridging cosmetic applications (facial cleansers, body washes) with surfactant engineering principles, this work establishes phase behavior-guided formulation strategies for personal care products.
本研究系统地阐明了氨基酸衍生表面活性剂混合组分体系中的泡沫动力学和消费者认知相关性。
采用pH梯度实验（5.5 - 10）结合动态泡沫分析来量化泡沫成核动力学。分子动力学模拟分析分子间相互作用，而脂质抗性评估则测量清洁效率。
SLG - CAB混合物将泡沫成核速度从35秒加快至20秒/100毫升（pH = 8.5），在统计学上显著优于商业基准（初始形成时间<5秒）。CAB的铵质子与SLG的羧酰胺氧之间形成的强氢键（键长：1.901 Å）实现了热力学稳定（ΔE = -53.04千卡/摩尔），增强了膜稳定性（Tfls 50% > 5分钟）。SLG - CAB产生单分散气泡（直径≈95μm），赋予“天鹅绒般”的感官特性，在pH 7 - 8时脂质清洁效率为74.74%（协同系数βs = -2.822）。
SLG - CAB体系展现出协同的泡沫增强和脂质抗性，在清洁应用中实现了“持久的乳脂感”。通过将表面活性剂工程原理与化妆品应用（洁面产品、沐浴露）相结合，本研究为个人护理产品建立了基于相行为指导的配方策略。
