[抗组胺药对缓激肽作用的影响]
[Effect of antihistaminics on bradykinin action].
作者信息
Shvarts G Ia
出版信息
Biull Eksp Biol Med. 1979 Oct;88(10):419-21.
PMID:40631
Abstract
On isolated ileum of the guinea pig the antihistamine drugs dimedrol, diprazin (pipolphen), tavegil and suprastin diminished spasmogenic effects of bradykinin and an enhancement of microvascular permeability induced by this polypeptid. The antihistamine drugs display a nonspecific antibradykinin activity. No relationship between the chemical structure and pronounced antibradykinin action of the antihistamines studied was revealed.
摘要
在豚鼠离体回肠上，抗组胺药苯海拉明、地哌嗪（哌泊非那嗪）、氯苯那敏和氯马斯汀可减弱缓激肽的致痉挛作用以及该多肽所诱导的微血管通透性增强。这些抗组胺药表现出非特异性抗缓激肽活性。在所研究的抗组胺药的化学结构与其明显的抗缓激肽作用之间未发现相关性。
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